Studies on Chlamydia Infections, Especially, on C. Pneumonia Strain TWAR and Sero-Clinical Epidemiology

衣原体感染，特别是肺炎衣原体菌株 TWAR 和血清临床流行病学研究

• 批准号: 63570356
• 负责人: SOEJIMA Rinzo
• 金额: $ 1.22万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570356/
• 关键词: Chlamydia; Chlamydia pneumonia strain TWAR; TWAR antibody; MFA; C. pneumonia infection; Respiratory infection; Seroepidemiology; MIC; C.pneumoniae感染症; Chlamydia pneumoniae; TWAR感染症; 分離; 培養細胞; クラミジア感染症; chlamydia TWAR株; マウス感染実験; 血清抗体価; 疫学調

1. Establishment of serodiagnostic method for C. Pneumonia infection.The specificity of the antibody titration by MFA was demonstrated in our serological study on mice after the infection, it seems to be useful for studing as eroepidemiology and clinical study for C. Pneumoniae infection.2. Seroepidemiology of C. Pneumonia infection.We carried out a seroepidemiological study on healthy individuals and patients with respiratory infections in the western part of Japan. Sera from 1745 cases (1987-1990) were used as the subjects. Positive serum antibodies (IgG fraction (]SY.gtoreq.[)64) against C. Pneumonia in adult were found, 67.4% of controls and 74.2% of patients, respectively. Very high titers of antibody (IgG (]SY.gtoreq.[)512 and IgA (]SY.gtored.[)128) against C. Pneumonia were found more frequently among the patients. As for sexes in carrying of the antibody in adults, significantly higher incidence was observed in men than in women. The primary seroconversion rates in both groups were 10% at age 5 or less but increased sharply after age 6 to reach 60% or more and almost leveled off thereafter.3. Clinical study of C. Pneumonia infection.We studied 22 cases of respiratory infection caused by C. Pneumonia, including one familial infection case. We also found an epidemic case in our nursing home.From these results, it suggested that C. Pneumonia is very commonly prevalent in Japan as well and plays a role as one of the important pathogens of respiratory infections.

1．肺炎衣原体感染血清学诊断方法的建立。我们对小鼠感染后的血清学研究证明了MFA滴定抗体的特异性，对肺炎衣原体感染的流行病学和临床研究具有一定的参考价值。 2．肺炎衣原体感染的血清流行病学。我们对日本西部地区的健康个体和呼吸道感染患者进行了血清流行病学研究。使用1745例（1987-1990）的血清作为研究对象。成人抗肺炎衣原体血清抗体（IgG 分数 (]SY.gtoreq.[)64）呈阳性，对照组和患者的比例分别为 67.4% 和 74.2%。患者中更频繁地发现针对肺炎衣原体的极高滴度抗体（IgG (]SY.gtoreq.[)512 和 IgA (]SY.gtored.[)128）。从成人携带抗体的性别来看，男性的发病率明显高于女性。两组的初次血清转化率在5岁或以下时均为10%，但在6岁后急剧上升，达到60%或以上，此后几乎趋于平稳。3．肺炎衣原体感染的临床研究。我们研究了22例肺炎衣原体引起的呼吸道感染病例，其中1例是家族性感染病例。我们的疗养院也发现了一例流行病例。从这些结果来看，衣原体肺炎在日本也很流行，是呼吸道感染的重要病原体之一。

项目成果

T. Kishimoto, M. Nakajima, Y. Nakagawa, et al.: "A case of Pneumonia caused by Chlamydia pneumonia, strain TWAR" Thw Journal of the Japanese Association for Infectious Diseases. 64. 510-515 (1990)

T. Kishimoto、M. Nakajima、Y. Nakakawa 等人：“肺炎衣原体 TWAR 株引起的肺炎一例”《日本传染病协会 Thw 杂志》。

岸本寿男: "Chlamydia pneumoniae TWAR株による感染症に関する研究、(第1報)-マウス感染実験並びにMFA法によるTWAR血清抗体価測定の検討-" 感染症学雑誌. 64. 124-131 (1990)

Hisao Kishimoto：“肺炎衣原体TWAR菌株引起的感染的研究，（第1次报告）-小鼠感染实验和通过MFA方法测定TWAR血清抗体滴度的检查-”传染病杂志64。124-131（1990）。

T. Kishimoto, Y. Nakagawa, J. Hino, R. soejima: "Prevalence of Humoral Antibodies to Chlamydia Pneumonia, Strain TWAR in Japan" Proceedings of the 16th International Congress of Chemotherapy. 508-1-2 (1989)

T. Kishimoto、Y. Nakakawa、J. Hino、R. soejima：“日本衣原体肺炎、TWAR 株体液抗体的流行”第 16 届国际化疗大会论文集。

岸本 寿男: "Chlamydia pneumoniae,(TWAR株)感染症に関する研究(第2報)ー健常者および急性呼吸器感染症患者における血清疫学的検討ー" 日本感染症学雑誌. 64(8). 986-993 (1990)

Hisao Kishimoto：“肺炎衣原体（TWAR 株）感染的研究（第 2 次报告）——健康受试者和急性呼吸道感染患者的血清流行病学研究”，《日本传染病杂志》64(8)（1990 年）。

副島 林造: "クラミジア:形態学的特徴と病原性の相違および臨床的特徴について" Mebio. 1月号. 13-17 (1991)

Rinzo Soejima：“衣原体：形态特征、致病性和临床特征的差异”Mebio 1 月 13-17 日。