Effects of methamphetamine on urinary levels of 2-phenylethylamine and phenylacetic acid.

甲基苯丙胺对尿中 2-苯乙胺和苯乙酸水平的影响。

• 批准号: 63570513
• 负责人: YAMADA Shigeto
• 金额: $ 1.15万
• 依托单位: INSTITUTE OF BRAIN DISEASES, KURUME UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570513/
• 关键词: METHAMPHETAMINE; 2-PHENYLETHYLAMINE; PHENYLACETIC ACID; GC-MS; βーフェニルチチラミン; フェニル酢酸; ラット

Effects of methamphetamine (MAP) on the metabolism of 2-phenyl- ethylamine (PEA) were investigated. Levels of urinary PEA and phenylacetic acid (PAA),which is major metabolite of PEA were determined in patients suffered from MAP psychosis or in rats treated with MAP by gas chromatography-mass spectrometry or gas chromatography. In patients urine which were collected on the first day of admission, MAP excretion had a significantly positive correlation (r=0.81, P<0.01, n=22) with PAA excretion, but not with PEA excretion. The amount of PAA in patients urine were higher than that of normal volunteers but not significant. On the other hand, PEA excretion in patients urine were significantly lower than that of normal volunteers. Urinary excretion of PAA in rats housed in metabolic cages were significantly increased by the administration of HAP (2mg/kg i.p.). On the other hand, the HAP treatment caused a significant reduction in urinary PEA level. These data suggest that HAP caused the enhancement of PEA disposition and PAA production which would be metabolized from PEA.

研究了甲基苯丙胺（MAP）对2-苯乙胺（PEA）代谢的影响。本文用气相色谱-质谱联用法和气相色谱法测定了MAP精神病患者和MAP治疗大鼠尿中PEA及其主要代谢产物苯乙酸（PAA）的含量。入院第1天尿MAP与PAA呈显著正相关（r=0.81，P<0.01，n=22），与PEA无相关性。患者尿中PAA含量高于正常人，但无显著性差异。另一方面，患者尿中PEA排泄量显著低于正常志愿者。在代谢笼中饲养的大鼠中，HAP（2 mg/kg i. p.）给药显著增加PAA的尿排泄。另一方面，HAP治疗引起尿PEA水平的显著降低。这些数据表明，HAP引起的PEA处置和PAA的生产，将从PEA代谢的增强。

项目成果

山田茂人,猪口隆洋,石橋正彦,横尾秀康,三木浩司,横山敏登,小島秀樹,西彰五郎,稲永和豊: "GC-MSによる生体試量中のMethamphetamine,2-pherylethylamineの同時定量" 日本医用マススペクトル学会講演集. 13. 161-164 (1988)

Shigeto Yamada、Takahiro Inoguchi、Masahiko Ishibashi、Hideyasu Yokoo、Koji Miki、Toshito Yokoyama、Hideki Kojima、Shogoro Nishi、Kazutoyo Inaga：“通过 GC-MS 同时测定生物样品中的甲基苯丙胺和 2-苯乙胺”日本学会会议录医学质谱法。13。161-164（1988）

山田茂人,石橋正彦,三根芳明,猪口隆洋,横山敏登,西彰五郎,稲永和豊: 薬物・精神・行動(Jpn.J.Psychopharmacol). 8. 151-152 (1988)

Shigeto Yamada、Masahiko Ishibashi、Yoshiaki Mine、Takahiro Inoguchi、Toshito Yokoyama、Shogoro Nishi、Kazutoyo Inaga：药物、精神病学和行为（Jpn.J.Psychopharmacol）（Jpn.J.Psychopharmacol）。

S.Yamada, M.Ishibashi, S.Nishi, H.Yokoo, T.Yokoyama: "Effect of methamphetamine on 2-phenylethylamine and phenylacetic acid excretion in human urine" Jpn.J.Psychopharmacol., 10 in press.

S.Yamada、M.Ishibashi、S.Nishi、H.Yokoo、T.Yokoyama：“甲基苯丙胺对人尿中 2-苯乙胺和苯乙酸排泄的影响”Jpn.J.Psychopharmacol.，10 期。

山田茂人,石橋正彦,西彰五郎,横尾秀康,横山敏登: "慢性覚醒剤中毒患者尿中の2ーphenylethylamineとphenylacetic acidの定量" 薬物・精神・行動(Jpn.J.Psychopharmacol.). 10. (1990)

Shigeto Yamada、Masahiko Ishibashi、Shogoro Nishi、Hideyasu Yokoo、Toshito Yokoyama：“慢性兴奋剂成瘾患者尿液中 2-苯乙胺和苯乙酸的测定”《药物、精神病学和行为》(Jpn.J.Psychopharmacol.)。 (1990)

山田茂人,石橋正彦,三根芳明,猪口隆洋,横山敏登,西彰五郎,稲永和豊: "メリンフェタミン慢性中毒患者作中のメタンフェタミンとフェニルエチラミン排泄" 薬物・精神・行動(Jpn.J.Psychopharmacol). 8. 151-152 (1988)

Shigeto Yamada、Masahiko Ishibashi、Yoshiaki Mine、Takahiro Inoguchi、Toshito Yokoyama、Shogoro Nishi、Kazutoyo Inaga：“慢性苯丙胺成瘾患者中的甲基苯丙胺和苯乙胺排泄”药物、精神病学和行为（Jpn.J. 8. 151-152（1988） ）