Effects of methamphetamine on urinary levels of 2-phenylethylamine and phenylacetic acid.

研究了甲基苯丙胺（MAP）对2-苯乙胺（PEA）代谢的影响。本文用气相色谱-质谱联用法和气相色谱法测定了MAP精神病患者和MAP治疗大鼠尿中PEA及其主要代谢产物苯乙酸（PAA）的含量。入院第1天尿MAP与PAA呈显著正相关（r=0.81，P<0.01，n=22），与PEA无相关性。患者尿中PAA含量高于正常人，但无显著性差异。另一方面，患者尿中PEA排泄量显著低于正常志愿者。在代谢笼中饲养的大鼠中，HAP（2 mg/kg i. p.）给药显著增加PAA的尿排泄。另一方面，HAP治疗引起尿PEA水平的显著降低。这些数据表明，HAP引起的PEA处置和PAA的生产，将从PEA代谢的增强。

Effects of methamphetamine (MAP) on the metabolism of 2-phenyl- ethylamine (PEA) were investigated. Levels of urinary PEA and phenylacetic acid (PAA),which is major metabolite of PEA were determined in patients suffered from MAP psychosis or in rats treated with MAP by gas chromatography-mass spectrometry or gas chromatography. In patients urine which were collected on the first day of admission, MAP excretion had a significantly positive correlation (r=0.81, P<0.01, n=22) with PAA excretion, but not with PEA excretion. The amount of PAA in patients urine were higher than that of normal volunteers but not significant. On the other hand, PEA excretion in patients urine were significantly lower than that of normal volunteers. Urinary excretion of PAA in rats housed in metabolic cages were significantly increased by the administration of HAP (2mg/kg i.p.). On the other hand, the HAP treatment caused a significant reduction in urinary PEA level. These data suggest that HAP caused the enhancement of PEA disposition and PAA production which would be metabolized from PEA.