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A prospective study to detect the factors to cause later cognitive decline or depressive state in Japanese elderly-Three years follow up study-

旨在探明日本老年人后期认知能力下降或抑郁状态的因素的前瞻性研究-三年跟踪研究-

基本信息

批准号：
22591290
负责人：
YAMADA Shigeto
金额：
$ 2.66万
依托单位：
Saga University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

We previously reported that the saliva level of 3-methoxy-4-hydroxyphenylglycole (sMHPG) in 214 elderly subjects living in a community was negatively associated with scores on the Mini-Mental State Examination (MMSE) or Frontal Assessment Battery (FAB) from 2004 to 2006 (Time A). To assess the contribution of sMHPG for consequent cognitive decline in elderly subjects living in a community, the same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). One hundred forty-seven of the original 214 subjects could be re-assessed using the same cognitive tests. FAB scores at Time B were significantly lower than at Time A. There was a significant negative correlation between baseline sMHPG levels and changes in FAB scores from time B to time A. Moreover, baseline sMHPG levels were negatively correlated with the FAB score at Time B, but not Time A. No correlation was found between baseline sMHPG levels and MMSE scores. High sMHPG could commit a consequent cognitive decline assessed by FAB in non-demented elderly subjects living in a community.

我们之前报道了2004年至2006年214名生活在社区的老年人唾液中3-甲氧基-4-羟基苯基甘油（sMHPG）水平与迷你精神状态检查（MMSE）或正面评估电池（FAB）分数呈负相关（时间a）。为了评估sMHPG对社区老年受试者认知能力下降的影响，同一队列在2007年至2009年再次进行了这些认知测试（时间B）。原来的214名受试者中的147人可以使用相同的认知测试进行重新评估。B时间的FAB评分显著低于a时间。基线sMHPG水平与FAB评分从B时间到a时间的变化呈显著负相关。此外，基线sMHPG水平与B时间的FAB评分呈负相关，但与a时间无关。高sMHPG可能导致生活在社区的非痴呆老年受试者的认知能力下降。