A prospective study to detect the factors to cause later cognitive decline or depressive state in Japanese elderly-Three years follow up study-

我们先前报道了2004年至2006年（时间A），214名居住在社区的老年受试者的唾液中3-甲氧基-4-羟基苯乙二醇（sMHPG）水平与简易精神状态检查（MMSE）或正面评估组合（FAB）评分呈负相关。为了评估sMHPG对生活在社区中的老年受试者随后认知下降的贡献，同一队列在2007年至2009年再次进行这些认知测试（时间B）。最初的214名受试者中有147名可以使用相同的认知测试进行重新评估。时间B的FA B评分显著低于时间A。基线sMHPG水平与从时间B至时间A的FA B评分变化之间存在显著负相关。此外，基线sMHPG水平与时间B的FA B评分呈负相关，但与时间A无关。基线sMHPG水平与MMSE评分之间无相关性。高sMHPG可能导致生活在社区中的非痴呆老年受试者的FAB评估的认知能力下降。

We previously reported that the saliva level of 3-methoxy-4-hydroxyphenylglycole (sMHPG) in 214 elderly subjects living in a community was negatively associated with scores on the Mini-Mental State Examination (MMSE) or Frontal Assessment Battery (FAB) from 2004 to 2006 (Time A). To assess the contribution of sMHPG for consequent cognitive decline in elderly subjects living in a community, the same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). One hundred forty-seven of the original 214 subjects could be re-assessed using the same cognitive tests. FAB scores at Time B were significantly lower than at Time A. There was a significant negative correlation between baseline sMHPG levels and changes in FAB scores from time B to time A. Moreover, baseline sMHPG levels were negatively correlated with the FAB score at Time B, but not Time A. No correlation was found between baseline sMHPG levels and MMSE scores. High sMHPG could commit a consequent cognitive decline assessed by FAB in non-demented elderly subjects living in a community.