Pathophysiology of water. electrolyte balance on surgical stress and application of therapy

为探讨外科应激时心钠素与水、电解质代谢的关系，观察了烧伤及内毒素诱导大鼠血浆心钠素及尿水、钠排泄的变化。此外，为了阐明心钠素多肽在烧伤应激中的生理意义，本研究采用心钠素多肽特异性抗血清，观察了手术应激大鼠被动免疫的效果，发现烧伤和内毒素诱导的大鼠血浆心钠素多肽水平持续升高。用兔心钠素特异性抗血清感染烧伤和内毒素诱导的大鼠，观察其利尿相。感染抗血清后，利尿、排钠作用明显受到抑制。提示心钠素在手术应激状态下对尿水钠排泄的调节中具有重要的生理作用。

To define the relationship between atrial natriuretci polypeptide and the metabolism of water and electrolytes in surgical stress, the changes of plasma hormonal levels, including atrial natriuretic polypeptide, and urinary water and sodium excretions were examined in the burned and endotoxin indenced rats. Moreover, to elucidate the physiological significance of atrial natriuretic polypepdtide in surgicall stress, the effect of passive immunization in the rats under surgical stress was investigated by using specific antiserum against atrial natriuretic poly peptide.Plasma atrial natriuretic polypeptide levels in burned and endotoxin induced rats were elevated for sustained periods. Specific rabbit antiserum for atial natriuretic polypeptide was infected to the burned and endotoxin induced rats during this diuretic phase. A significant inhibit ion of diureses and natriuresis was observed after infection of antiserum. These results provide evidence indication that atrial natriuretic polypeptide plays a phsiological role in the regulation of urinary water and soduim excretion in surgical stress.