Pathophysiology of water. electrolyte balance on surgical stress and application of therapy

水的病理生理学。

• 批准号: 63570611
• 负责人: UEDA Masakazu
• 金额: $ 1.34万
• 依托单位: Department of Surgery, School of Medicine, Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570611/
• 关键词: Surgical Stress; Water.electrolyte balance; ANP; Endotoxin shock; ARDS; Shock; エンドトキシンショック; 急性呼吸不全; 末梢循環不全; 心房性Na利尿ペプチド(ANP); 生理作用; 薬理作用; Endotoxin shock; 熱傷

To define the relationship between atrial natriuretci polypeptide and the metabolism of water and electrolytes in surgical stress, the changes of plasma hormonal levels, including atrial natriuretic polypeptide, and urinary water and sodium excretions were examined in the burned and endotoxin indenced rats. Moreover, to elucidate the physiological significance of atrial natriuretic polypepdtide in surgicall stress, the effect of passive immunization in the rats under surgical stress was investigated by using specific antiserum against atrial natriuretic poly peptide.Plasma atrial natriuretic polypeptide levels in burned and endotoxin induced rats were elevated for sustained periods. Specific rabbit antiserum for atial natriuretic polypeptide was infected to the burned and endotoxin induced rats during this diuretic phase. A significant inhibit ion of diureses and natriuresis was observed after infection of antiserum. These results provide evidence indication that atrial natriuretic polypeptide plays a phsiological role in the regulation of urinary water and soduim excretion in surgical stress.

为探讨心房利钠多肽与手术应激时水和电解质代谢的关系，本实验观察了烫伤和内毒素致伤大鼠血浆心钠素、尿钠排泄量和血浆心钠素水平的变化。此外，为了阐明心钠素在手术应激中的生理意义，用抗心钠素多肽的特异性抗血清观察了被动免疫对手术应激大鼠的影响。烧伤和内毒素诱导的大鼠血浆心钠素水平持续升高。在此利尿期，用兔抗心钠素多肽的抗血清感染烧伤和内毒素诱导的大鼠。抗血清感染后对利尿剂和利钠排泄有明显的抑制作用。这些结果表明，心钠素在手术应激时调节尿水和尿钠排泄中起着生理学作用。

项目成果

Wakabayashi.G., Ueda.M., Aikawa.N, Naruse.M. and Abe.O: "Release of ANP and its physiological role in pulmondry injury due to HCl" Amer.J, Physiol.

若林.G.、上田.M.、相川.N、成濑.M.

Wakabayashi G.: "Release of ANP and its physiological role in pulmonary injury due to HCl" Amer.J.Physiol.

Wakabayashi G.：“ANP 的释放及其在 HCl 引起的肺损伤中的生理作用”Amer.J.Physiol。

Wakabayashi G.: "Atrial natriuretic polypeptide after burn injury:Blood level and physiological role in rats." Burns.

Wakabayashi G.：“烧伤后心房钠尿多肽：大鼠的血液水平和生理作用。”

上田政和: 外科と代謝・栄養. 22. 332 (1988)

Masakazu Ueda：手术、新陈代谢和营养。22. 332 (1988)

Wakabayashi,G: "Atrial natriuretic polypeptide after burn injury:Blood level and physiological role in rats" Burns.

Wakabayashi，G：“烧伤后心房钠尿多肽：大鼠的血液水平和生理作用”烧伤。