Study on the metastatic capability of lung cancer in terms of cell biological properties.

1)比较肺腺癌(115例)和肺鳞癌(82例)根治性切除后血行转移的临床病理因素。在转移相关因素方面，腺癌与鳞癌有明显差异。结果提示，肺腺癌和肺鳞癌的血行转移有不同的影响因素。2)测定了76例肺癌患者血清层粘连蛋白的浓度。层粘连蛋白是基底膜的一种成分，在血行转移过程中介导肿瘤细胞与血管成分的黏附。小细胞癌和鳞癌患者血清中层粘连蛋白浓度异常升高。一些单元格Li…3)我们测定了肺癌组织提取液中DNA合成挽救途径中的胸苷激酶(TK)的活性。术后复发患者肿瘤提取液中TK活性明显高于未复发患者。提示肿瘤组织中TK活性可能是肿瘤转移的有用标志物。4)临床研究旨在建立肺癌复发的策略。对9例肺癌肺叶切除术后肺转移的局限性手术治疗进行了研究。复发性肺癌的有限手术治疗效果良好，术后5年生存率为60%。有人认为，对此类患者进行有限的手术可能是一种有益的治疗方式。我们强调了建立肺癌复发高危人群和早期诊断的重要性。较少

A goal of our study is to elucidate cell biological properties that have influence on metastatic capability in lung cancer.1) A comparative study between adenocarcinoma (115 cases) and squamous cell carcinoma (82 cases) of the lung on clinicopathological factors was performed in relation to hematogenous metastasis after curative resection. Concerning the factors related to metastasis, a clear difference between adenocarcinoma and squamous cell carcinoma was observed. Our results suggest that there are different factors influencing hematogenous metastasis in adenocarcinoma and squamous cell carcinoma of the lung.2) Laminin concentration in sera of lung cancer patients (76 cases) was measured. Laminin, one of constituents in basement membrane, has been suggested as mediating tumor cell attachment to vascular components in the course of hematogenous metastasis. Patients with small cell carcinoma and squamous cell carcinoma showed abnormally high laminin concentration in sera. Some cell li … More nes established from human lung cancer were revealed to produce lanminin in vitro.3) We measured the activity of thymidine kinase (TK), one of the enzymes in the activity in the salvage pathway of DNA synthesis, in the extract of resected lung tumors. TK activity in the tumor extract from the patients with recurrence after resection was significantly higher than that from the patients without recurrence. This suggest that TK activity in tumor extract may be a useful marker for cancer metastasis.4) Clinical study was performed to establish the strategy for lung cancer recurrence. Limited operation for lung cancer pulmonary metastasis after lobectomy was studied in nine cases. Limited operation for recurrent lung cancer showed good outcome in this series and 5-year survival was 60% postoperatively. It was suggested that limited operation for such selected patients can be a beneficial therapeutic modality. We emphasized the importance to set up a high risk group for lung cancer recurrence and early diagnosis for it. Less