Study on the metastatic capability of lung cancer in terms of cell biological properties.

从细胞生物学特性研究肺癌转移能力。

• 批准号: 63570658
• 负责人: SHIBA Mitsutoshi
• 金额: $ 0.96万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570658/
• 关键词: LUNG CANCER; METASTASIS; LAMININ; THYMIDINE KINASE; LIMITED OPERATION

A goal of our study is to elucidate cell biological properties that have influence on metastatic capability in lung cancer.1) A comparative study between adenocarcinoma (115 cases) and squamous cell carcinoma (82 cases) of the lung on clinicopathological factors was performed in relation to hematogenous metastasis after curative resection. Concerning the factors related to metastasis, a clear difference between adenocarcinoma and squamous cell carcinoma was observed. Our results suggest that there are different factors influencing hematogenous metastasis in adenocarcinoma and squamous cell carcinoma of the lung.2) Laminin concentration in sera of lung cancer patients (76 cases) was measured. Laminin, one of constituents in basement membrane, has been suggested as mediating tumor cell attachment to vascular components in the course of hematogenous metastasis. Patients with small cell carcinoma and squamous cell carcinoma showed abnormally high laminin concentration in sera. Some cell li … More nes established from human lung cancer were revealed to produce lanminin in vitro.3) We measured the activity of thymidine kinase (TK), one of the enzymes in the activity in the salvage pathway of DNA synthesis, in the extract of resected lung tumors. TK activity in the tumor extract from the patients with recurrence after resection was significantly higher than that from the patients without recurrence. This suggest that TK activity in tumor extract may be a useful marker for cancer metastasis.4) Clinical study was performed to establish the strategy for lung cancer recurrence. Limited operation for lung cancer pulmonary metastasis after lobectomy was studied in nine cases. Limited operation for recurrent lung cancer showed good outcome in this series and 5-year survival was 60% postoperatively. It was suggested that limited operation for such selected patients can be a beneficial therapeutic modality. We emphasized the importance to set up a high risk group for lung cancer recurrence and early diagnosis for it. Less

本研究的目的是阐明细胞生物学特性对肺癌转移能力的影响。1）对肺腺癌（115例）和肺鳞癌（82例）的临床病理因素进行了比较研究，探讨了与肺腺癌和肺鳞癌根治性切除术后血行转移相关的临床病理因素。关于转移的相关因素，腺癌和鳞状细胞癌之间观察到明显的差异。提示肺腺癌和肺鳞癌血行转移的影响因素不同。2）测定76例肺癌患者血清层粘连蛋白（Laminin）浓度。层粘连蛋白是基底膜的组成成分之一，在肿瘤血行转移过程中介导了肿瘤细胞与血管成分的粘附。小细胞癌和鳞状细胞癌患者血清层粘连蛋白浓度异常增高。一些手机 ...更多信息 从人肺癌中建立的内斯在体外显示产生lanminin。3）我们测量了切除的肺肿瘤提取物中胸苷激酶（TK）的活性，TK是DNA合成的补救途径中的活性酶之一。肿瘤切除后复发患者肿瘤提取液中TK活性显著高于无复发患者。提示肿瘤提取物中TK活性可能是一个有用的肿瘤转移标志物。4）进行临床研究以建立肺癌复发的策略。本文报告9例肺癌肺叶切除术后肺转移的有限手术治疗。复发性肺癌的有限手术治疗效果良好，术后5年生存率为60%。因此，对此类患者进行有限的手术治疗是一种有益的治疗方式。我们强调了建立肺癌复发高危人群和早期诊断的重要性。减

项目成果

柴光年、他: "肺癌に対する縮小手術について" 胸部疾患学会誌. 28(2).

Mitsutoshi Shiba 等人：“肺癌缩小手术”，胸科疾病学会杂志 28(2)。

Toshikazu Yusa, et al.: "Comparison of Adenocarcinoma and Squamous Cell Carcinoma of the Lung in terms of Clinicopathological Factors Related to Hematogenous Metastasis after Curative Resection." Haigan, 30-1, 35-41, 1990.

Toshikazu Yusa 等人：“肺腺癌和鳞状细胞癌在与根治性切除后血行转移相关的临床病理因素方面的比较”。

由佐俊和,他: "治癒切除後の再発に関する臨床的検討" 肺癌. 30. (1990)

Toshikazu Yusa 等人：“治愈性切除术后复发的临床研究”30。(1990)

Toshikazu Yusa, et al.: "Clinical study on recurrence of lung cancer in patients who underwent curative surgical resection." Haigan, 30, 1990.

Toshikazu Yusa 等人：“接受根治性手术切除的患者肺癌复发的临床研究。”

Mitsutoshi Shiba, et al.: "Limited Operation for Lung Carcinoma to Preserve Lung Function." Japanese Journal of Thoracic Diseases, 28.

Mitsutoshi Shiba 等人：“肺癌的有限手术以保留肺功能。”