Teratogenicity Caused by Anesthetic Gas and Changes Depending on O_2 Concentration.

在器官发生期暴露于麻醉气体的有害条件下，对其致畸性进行了研究。在此实验之前，有报道称，在器官发生期间，将0.5%氟烷均匀暴露8小时，可发生腭裂。实验动物为ddy A/J系小鼠。将妊娠第11天的大鼠在0.;5% ~ 1.0%的浓度条件下（o2浓度21%、60%、100%）连续暴露8 h。于妊娠第18天行剖宫产，检查胎儿是否有异常。从本实验结果来看，1)以2升/ min的速度暴露于1.0%的安氟醚时，两品系小鼠均未见腭裂，而a /J品系小鼠的腭裂率高达14.2%。2)氟烷和安氟醚引起A/J品系小鼠腭裂的发生。3)在此条件下，安氟醚的出现率低于氟烷。4)我们认为，通过提高麻醉气体中氧气的浓度，可以在一定程度上防止A/J系小鼠腭裂发生率的降低（60% O_2组和100% O_2组）。5)比较了氟醚、安氟醚、五氟醚的致畸性。

We were examined the teratogenicity under the detrimental condition being exposed to the anesthetic gas in organogenesis period. Prior to this experiment, it was reported that cleft palate occurred, when uniformly exposed to 0.5% halothane for 8 hours during the organogenesis period. The animals used in this study were ddy A/J strain mice. The animals in the 11th day of gestation were exposed to 0.5-1.0% enflurane for 8 hours under three different conditions (O_2 concentration : 21%, 60% and 100%). Cesarean section was performed on the 18th day of gestation and the fetuses were examined for the presence of abnormalities.From the results of this experiment,1) When two strains of mice were exposed to 1.0% enflurane at 2 liters / min., there was none observed with cleft palate in the ddy strain mice, but observed a high rate of 14.2% in the A/J strain mice.2) Halothane and enflurane caused the occurrence of cleft palate in the A/J strain mice.3) The rate of occurrence of enflurane was lower than that of halothane under this condition.4) We suggested that the decreasing occurrence of cleft palate (in the 60% O_2 and 100% O_2 groups) in the A/J strain mice was possible to prevent a certain extent by increasing the concentration of oxygen in the anesthetic gas.5) We compared the teratogenicity of halothance, enflurane, seroflurane.