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Organ Specificity in the responses of isolated arteries to anesthetics.

孤立动脉对麻醉剂反应的器官特异性。

基本信息

批准号：
63570722
负责人：
HATANO Yoshio
金额：
$ 1.41万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570722/
关键词：
Vascular smooth muscle Barbiturates Halothane Isoflurane Cerebral artery Coronary artery Organ blood flow バルビッレ-ト肝血流 αー受容体

项目摘要

The present study attempts to clarify the organ specificity in the responses to anesthetics of isolated arteries of different organs (cerebral, coronary, mesenteric, renal and femoral arteries). (1) In arterial strips under resting tension, the addition of thiamylal and thiopental(10^<-5> to 10^<-3> M) caused a dose-related contraction; the contraction was significantly more intense in cerebral than in extracerebral arteries. Secobarbital and pentobarbital failed to produce a significant contraction. Thiobarbiturates-induced contraction was attenuated by Ca channel blockers and abolished by the removal of Ca^<++> from extracellular fluids.(2) In arterial strips previously contracted with KC1 or prostaglandin F_2alpha (PGF_<>alpha), thiobarbiturates in low concentrations (<10^<-4> M) produced a further contraction and in high concentrations (>3x10^<-4> M) a profound relaxation, indicating that thiobarbiturates possess biphasic effects. By contrast, oxybarbiturates were revealed to possess only relaxing effect.(3) Regional difference of the response to halothane and isoflurane of large (>2.0 mm, OD) and small (<1.0 mm, OD) was investigated. Halothane (1-3 MAC) and nitroglycerin (NTG, 10^<-9> to 10^<-5> m) were revealed to produce greater relaxations in large than in small coronary arteries, and in contrast, isoflxirane (1-3 MAC) and adenosine (10^<-7> to 10^<-4> m) was revealed to produce relaxations greater in small than in large coronary arteries.These findings with isolated arteries from different organ suggest that the vascular effects of anethetics are uniform in different organs. These different effects may contribute to maldistribution of blood flow during anesthesia.

本研究试图阐明不同器官（脑动脉、冠状动脉、肠系膜动脉、肾动脉和股动脉）离体动脉对麻醉剂反应的器官特异性。(1)在静息张力下的动脉条带中，添加硫胺醛和硫喷妥钠（10^<-5> M至10^<-3> M）引起剂量相关收缩；脑动脉的收缩明显强于脑外动脉。西巴比妥和戊巴比妥不能产生明显的收缩。Ca通道阻滞剂可减弱硫代巴比妥类药物引起的收缩，并可通过从细胞外液中去除Ca^<++>而消除。(2)在先前由KC1或前列腺素f_2α (PGF_<> α)收缩的动脉条带中，低浓度（<10^<-4> M）的硫代巴比妥类药物产生进一步收缩，高浓度（>3x10^<-4> M）的硫代巴比妥类药物产生深度松弛，表明硫代巴比妥类药物具有双相作用。相比之下，奥氧巴比妥类药物仅具有放松作用。(3)考察了大（>2.0 mm， OD）和小（<1.0 mm， OD）对氟烷和异氟烷响应的区域差异。氟烷（1-3 MAC）和硝酸甘油（NTG, 10^<-9>至10^<-5 >m）在大冠状动脉中产生比小冠状动脉更大的舒张，相反，异氟烷（1-3 MAC）和腺苷（10^<-7>至10^<-4 >m）在小冠状动脉中产生比大冠状动脉更大的舒张。这些来自不同器官的分离动脉的结果表明，麻醉剂对血管的影响在不同器官中是均匀的。这些不同的作用可能导致麻醉期间血流的不均匀分布。