Development of Multifunctional Liquid-Liquid Oxygenator

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Hyperbaric liquid-liquid oxygenator made of ethylene vinyl alcohol copolymer (EVA) hollow fiber was developed in which gas exchange took place between venous blood and oxygen carrier solution such as saline, dialysate, or artificial blood (FC43). Oxygen carrier solution was saturated in the air-tight circuit with hyperbaric (up to 1.0 atm added) pure oxygen across the EVA membrane which is known to need small amount of heparin in use for hemodialysis. High pressure (Ps) was controlled with a pressure regulator, and oxygen flow rate, by a mass flowmeter. Solution at 37^ﾟC shifted at the rate of 0.94ml/min per at the transmembrane pressure of 10 mmHg in the oxygenator (0.8m^2) into the blood circuit. Shifted solution into the blood circuit was ultrafiltrated with a dialyzer interposed in the downstream circuit and recirculated to the pressurized circuit.This system working not only as an oxygenator but also as a hemodialyzer with small amount of heparin and without plasma leakage is suitable for ECMO for a neonate.