STUDY ON REAL-TIME MEASUREMENT OF CARDIAC MUSCLE VISCOELASTICITY USING AN ULTRASONIC TACTILE MICROSENSOR CATHETER

超声触觉微传感器导管实时测量心肌粘弹性的研究

• 批准号: 08458296
• 负责人: TSUJI Takayuki
• 金额: $ 4.8万
• 依托单位: NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08458296/
• 关键词: ultrasonic tactile sensor; resonant frequency shift; microtip catheter; viscoelasticity; beating heart muscle; in vivo organ viscoelasticity

Aim of the project is to develop a tactile sensor catheter having 1.5 mm in diameter equipped with the 200 kHz ultrasonic microtip that can detect in real-time viscoelasticity change of beating heart muscle. Influence of contact pressure of the tip on the objects which are silicone rubber discs having various silicone contents from 40 to"90 % was studied by varying tip weight loaded with various sizes of lead chips from 5 to 100 g. Ultrasonic resonant frequency shift (DELTAf) depended on the tip load. Five gram load was decided appropriate for measuring soft tissues.The negative DELTAf became bigger in softer material. Viscoelasticity measurements of in vivo organs including liver, kidney, spleen and muscles in anesthetized dogs revealed the DELTAf of muscle was smaller than other tissues. Skeletal muscle, kidney, liver and spleen were softer in order. Dynamic changes associated with the left ventricular wall motion was obtained by the catheter inserted via carotid artery However, the signals originating from viscoelasticity changes of the ventricular muscle and from the tip collision against the ventricular wall in systole cannot be discriminated. Improvement of the catheter should be necessary for this purpose.

本项目的目的是研制一种直径1.5 mm的触觉传感器导管，该导管配有200 kHz的超声微尖，可以实时检测心脏跳动肌肉的粘弹性变化。研究了不同硅胶含量(40%~90%)的硅橡胶圆盘在不同重量下加载不同尺寸的铅片(5~100g)时，针尖接触压力对硅橡胶圆盘的影响。软组织的测量以5g负荷为宜，软质材料的负DELTAf变大。对麻醉犬肝、肾、脾和肌肉等活体器官的粘弹性测量表明，肌肉的DELTAf小于其他组织。骨骼肌、肾、肝、脾依次较软。经颈动脉插管可获得与室壁运动相关的动态变化，但不能区分来自室肌粘弹性变化的信号和收缩时尖端与室壁的碰撞信号。为此，有必要对导管进行改进。

项目成果

Murata M, Tsuji T, et al: "Measurement of stiffness of organs in vivo with an ultrasonic tactile sensor" Proceedngs of World Congress on Medical Physics and Biomadical Engineering. 132-132 (1997)

Murata M、Tsuji T 等人：“使用超声波触觉传感器测量体内器官的硬度”世界医学物理和生物医学工程大会论文集。

村田正典: "超音波共振カテーテルによるイヌ左室壁粘弾性動的計測" 第19回日本バイオレオロジー学会年会抄録集. 49 (1996)

Masanori Murata：“使用超声波共振导管动态测量犬左心室壁粘弹性”第 19 届日本生物流变学会年会记录 49 (1996)。

村田正典: "超音波触覚カテーテルによるイヌ左室壁粘弾性のリアルタイム計測" 医用電子と生体工学 第35回日本ME学会大会論文集. Vol.34. 227 (1996)

Masanori Murata：“使用超声波触觉导管实时测量犬左心室壁粘弹性”第 35 届日本 ME 学会会议记录医学电子学和生物工程第 34 卷（1996 年）。

村田正典: "超音波触覚カテーテルによるイヌ左室壁粘弾性のリアルタイム計測" 第7回バイオエンジニアリング学術講演会・夏季セミナー講演論文集. 96-29. 227 (1996)

Masanori Murata：“使用超声触觉导管实时测量犬左心室壁粘弹性”第七届生物工程学术会议/夏季研讨会论文集96-29（1996）。

Murata M,Tsuji T,et al: "Measurement of stiffness of organs in vivo with an ultrasonic tactile sensor" Proceedings of World Congress on Medical Physics and Biomadical Engineering. 132-132 (1997)

Murata M、Tsuji T 等人：“使用超声波触觉传感器测量体内器官的硬度”世界医学物理和生物医学工程大会论文集。