Neurochemical analysis on a brain of pure pallidal degeneration with special reference to the termination of GABA ergic pallido-thalamic tract in the thalamus
对纯苍白球变性大脑的神经化学分析,特别涉及丘脑中 GABA 能苍白球丘脑束的终止
基本信息
- 批准号:01570441
- 负责人:
- 金额:$ 1.02万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1989
- 资助国家:日本
- 起止时间:1989 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1) Neurotransmitter markers were measured in brain regions of a very rare case of pure pallidal degeneration (PPD) as compared with 16 controls. Gamma-aminobutylate (GABA) concentration was remarkably decreased in extemal (GPe) and internal (GPi) pallidum (GP) and subthalamic nucleus (ST), glutamate concentration was increased markedly in GPi and ST, and choline acetyltransferase (CHAT) activities in GP, ST, ventroanterior (VA) and ventrolateral (VL) nucleus of the thalamus. Noradrenaline concentration in GP was decreased moderately. Dopaminergic and serotonergic systems showed no remarkable change in all the regions examined. These results suggest that the changes of neurotransmitter markers reflect selective degeneration of GP neurons and their efferent fibers, and also of terminals of striatopallidal GABAergic fibers and probably noradrenergic fibers within GP. Because ChAT activities were increased only in GP and its terminal areas, increase of ChAT activity might be a representation of a compensatory reaction against GP neuronal damage in PPD brain. These sets of neurochemical changes are the pathophysiological basis of the characteristic slow movement in PPD patient. 2) Using microdissection method, fine distribution of GABA in the thalamus was analyzed in PPD and 4 control brains. GABA concentration was specifically decreased in PPD brain in the ventro-oral nucleus of VL, which indicates that pallidothalamic fibers contain GABA as a neurotransmitter in the human brain and terminate in the very restricted area of VL thalamus.
1)神经递质标记物测量的一个非常罕见的情况下,纯苍白球变性(PPD)的大脑区域相比,16个控制。苍白球(GP)外侧核(GPe)、苍白球内侧核(GPi)和丘脑底核(ST)γ-氨基丁酸(GABA)含量显著降低,苍白球内侧核(GPi)和丘脑底核(ST)谷氨酸含量显著升高,苍白球外侧核(ST)、丘脑腹前核(VA)和腹外侧核(VL)胆碱乙酰转移酶(CHAT)活性显著升高。GP中去甲肾上腺素浓度中度降低。多巴胺能和多巴胺能系统在所有检查的区域中没有显着变化。这些结果提示,神经递质标记物的变化反映了GP神经元及其传出纤维的选择性变性,也反映了GP内GABA能纤维终末的选择性变性,可能还反映了GP内去甲肾上腺素能纤维终末的选择性变性。由于ChAT活性仅在GP及其终末区增加,ChAT活性的增加可能是PPD脑对GP神经元损伤的代偿反应。这些神经化学变化是PPD患者运动迟缓的病理生理基础。2)采用显微解剖方法,对PPD和4例正常对照组丘脑内GABA的精细分布进行了分析。GABA浓度在PPD脑中VL的腹口核中特异性降低,这表明苍白球丘脑纤维含有GABA作为人脑中的神经递质,并终止于VL丘脑的非常有限的区域。
项目成果
期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Shinozaki,H: "Specific lesions of rat spinal interneurons induced by systemic administration of acromelic acid,a new potent kainate analogue." Brain Research. 503. 330-333 (1989)
Shinozaki,H:“全身施用一种新的有效红藻氨酸类似物 acromelic 酸可引起大鼠脊髓中间神经元的特定损伤。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Aizawa H., Kwak S., Shimizu T., Shibasaki H.& Mannen T.: "Neurochemical analysis on a brain of pure pallidal degeneration." J.Nuerol.Sci.
相泽 H.、郭 S.、清水 T.、柴崎 H.
- DOI:
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- 影响因子:0
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貫名信行: "アルツハイマ-病における異常蛋白質" 蛋白質核酸酵素. 34. 1725-1732 (1989)
Nobuyuki Nukina:“阿尔茨海默病中的异常蛋白质”蛋白质核酸酶。34。1725-1732 (1989)
- DOI:
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- 影响因子:0
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相澤仁志: "脳神経伝達物質" 臨床成人病. 19. 1313-1319 (1989)
Hitoshi Aizawa:“颅神经递质”临床成人疾病。19. 1313-1319 (1989)
- DOI:
- 发表时间:
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- 影响因子:0
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Aizawa H.: "Selective decrease of GABA concentration in the specific thalamic nuclei of pallidal degeneration." J.Neurological Sciences.
Aizawa H.:“苍白球变性的特定丘脑核中 GABA 浓度的选择性降低。”
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- 影响因子:0
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KWAK Shin其他文献
KWAK Shin的其他文献
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{{ truncateString('KWAK Shin', 18)}}的其他基金
Roles of excitotoxicity in pathogenesis of degenerative neurological diseases
兴奋性毒性在退行性神经系统疾病发病机制中的作用
- 批准号:
22390173 - 财政年份:2010
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular mechanism underlying death of motor neurons in model mice of amyotrophic lateral sclerosis
肌萎缩侧索硬化模型小鼠运动神经元死亡的分子机制
- 批准号:
19390235 - 财政年份:2007
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Production of sporadic ALS model mice by targeting the ADAR2 gene in motor neurons
通过靶向运动神经元中的 ADAR2 基因制备散发性 ALS 模型小鼠
- 批准号:
17390251 - 财政年份:2005
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular changes of AMPA receptors in ALS
ALS 中 AMPA 受体的分子变化
- 批准号:
10670575 - 财政年份:1998
- 资助金额:
$ 1.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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