Serological studies on mother-to-child transmission and virulence as an opportunistic pathogen of human herpesvirus-6 (HHV-6)

人类疱疹病毒 6 (HHV-6) 母婴传播和毒力的血清学研究

• 批准号: 01570539
• 负责人: MIYAZAKI Chiaki
• 金额: $ 1.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570539/
• 关键词: Human herpesvirus-6; Exanthema subitum; Mother-to-Child Transmission; Horizontal transmission; Reactivation; Reinfection

The clinical findings of 47 patients with exanthema subitum (ES) serologically confirmed human herpesvirus-6 (HHV-6) infection were analyzed. The onset age of ES concentrated between 6 and 9 months old, pepeaked at 6 months old. In our seroepidemiologic study, the maternal antibody to HHV-6 disappeared within the same period. Among the 47 patients. 3 were attacked by ES within 2 months after their birth and all of their mothers mothers were seropositive. These results suggested that the onset age of ES is determined by the disappearance of maternal antibody to HHV-6. No correlation was observed between the onset age and mode of feeding (e.g. breast bottle and mixed).Antibodies to HHV-6 in the infants who have been admitted in the neonatal intensive care unit (NICU) for more than 1 year were tested together with their mothers. All of their mothers were seropositive to HHV-6 and 5 of the 6 infants were seropositive to HHV-6. Furthermore. 21 children who have been admitted in an orphanage … More before 3 month of ages were tested for their antibodies to HHV-6. Age specific seroprevalence of HHV-6 in these children was similar to that of the ordinary child population. These data elucidated that intimate contact of mother and child is not neccesary for the establishment of HHV-6 infection in infants.In order to obtain basic data concerning the virulence of HHV-6 in the immunocompromised state, we evaluated whether or not reactivation or reinfection of HHV-6 occurs as other herpesviruses. Among the 23 patients with second attacks of ES. 3 showed significant rises in the HHV-6 lgG antibody titers and 2 of the 5 patients with previous afebrile attacks also showed rises. These results suggest possible role of HHV-6 reactivation or reinfection in some second attack of ES.We have obtained informations from 57 pediatricians who had been trained at Kyushu University Hospital on the history of ES of their own children older than 12 months of age by a questionnaire. Seventy of 115 their children (61%) have had clinical ES. This attack rate of ES in Japan is much higher than that in U. S. A. (approximately 30%). Less

本文分析了47例经血清学证实的人类疱疹病毒6型（HHV-6）感染患者的临床表现。ES的发病年龄集中在6 ~ 9月龄，高峰在6月龄。在我们的血清流行病学研究中，母亲对HHV-6的抗体在同一时期消失。47例患者中。3例在出生后2个月内感染ES，其母亲均为血清学阳性。提示ES的发病年龄与母源抗HHV-6抗体的消失有关。对新生儿重症监护室（NICU）住院1年以上的患儿与其母亲进行HHV-6抗体检测。所有母亲均为HHV-6阳性，6名婴儿中有5名HHV-6阳性。此外。21名被孤儿院接纳的儿童 ...更多信息 3月龄前检测HHV-6抗体。年龄别HHV-6阳性率与普通儿童相似。这些数据表明，母亲和孩子的亲密接触是不必要的建立HHV-6感染的infant. To获得有关HHV-6在免疫功能低下状态下的毒力的基本数据，我们评估是否HHV-6的再激活或再感染发生其他疱疹病毒。23例ES再次发作者。3例HHV-6 IgG抗体滴度显著升高，5例既往无发热发作的患者中有2例也显示升高。这些结果表明可能的作用HHV-6的再激活或再感染的一些第二次攻击的ES。我们已经获得了信息，从57名儿科医生谁曾在九州大学医院培训的历史上ES自己的孩子年龄超过12个月的问卷调查。他们的115个孩子中有70个（61%）有临床ES。日本的ES发病率远高于美国。S. A.（约30%）。少

项目成果

Kohji UEDA: "EXANTHEM SUBITUM AND ANTIBODY TO HUMAN HERPESVIRUS-6" Journal of Infectious Diseases. 159. 750-752 (1989)

Kohji UEDA：“EXANTHEM SUBITUM 和人类疱疹病毒 6 抗体”传染病杂志。

岡田賢司: "Human herpesvirus-6(HHV-6)感染症の臨床像" 小児科. 31. 105-111 (1990)

Kenji Okada：“人类疱疹病毒 6 (HHV-6) 感染的临床特征”《儿科学》31. 105-111 (1990)。

Kohji Ueda, Koichi Kusuhara, Mizuo Hirose, Kenji Okada, Chiaki Miyazaki, Ken Tokugawa, Minako Nakayama and Koichi Yamanishi.: "Exanthem subitum and antibody to human herpesvirus-6." J. Infect. Dis. 159. 750-752 (1989)

Kohji Ueda、Koichi Kusuhara、Mizuo Hirose、Kenji Okada、Chiaki Miyazaki、Ken Tokukawa、Minako Nakayama 和 Koichi Yamanishi.：“Exanthem subitum 和人类疱疹病毒 6 抗体。”

Koichi Kusuhara, Kohji Ueda, Keiji Okada, Chiaki Miyazaki, Ken Tokugawa, Mizuo Hirose, Kazuo Takahashi, Koichi Yamanishi.: "Do second attacks of exanthema subitum result from human herpesvirus 6 reactivation or reinfection." Pediatr. Infect. Dis. J.10. 46

Koichi Kusuhara、Kohji Ueda、Keiji Okada、Chiaki Miyazaki、Ken Tokukawa、Mizuo Hirose、Kazuo Takahashi、Koichi Yamanishi.：“第二次发作的小红疹是由人类疱疹病毒 6 重新激活或再感染引起的吗？”

Kenji OKADA: "EXANTHEMA SUBITUM:RELATIONSHIP WITH HUMAN HERPESVIRUS-6(HHV-6)INFECTION" Pediatric Infectious Disease Journal. 投稿中.

Kenji Okada：“急疹：与人类疱疹病毒 6(HHV-6) 感染的关系”《儿科传染病杂志》目前正在提交。