Chronobiological study on affective disorders using auto-regressive modelling. (Analysis of the relationship between HPA axis ans NA system)

使用自回归模型对情感障碍进行时间生物学研究。

• 批准号: 01570615
• 负责人: MIZUNO Shoji
• 金额: $ 1.34万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570615/
• 关键词: chronobiology; HPA-axis; noradrenergic activity; manic-depressive disorder; plasma cortisol; plasma MHPG; core body temperature; autoregressive modelling

The present study was designed to examine the chronobiological abnormalities of the HPA-axis and the noradrenergic activity in manic-depressive disorder.1. Circadian rhythms of plasma cortisol, plasma free and total MHPG, and core body temperature were compared in five bipolar patients and 10 normal controls. An earlier acrophase of plasma cortisol and a lower level of plasma free MHPG were observed13EA\ : in the patient group. One of the patients was examined repeatedly in different clinical states. The level of total MHPG was higher in a manic state and the acrophase of cortisol earlier in a depressive state.2. Five bipolar patients and four controls were studied longitudianally. Blood samples were obtained every 1-4 week for about a year. Plasma cortisol, plasma free and total MHPG were measured and the clinical state was estimated using the HRSD or th13EA\ : e manic rating scale of Petterson. In the patient group the level of plasma cortisol was lower. The coefficient of variation of cortisol level of each patient was higher. A patient with rapid-cycling showed a significant correlation between the mani13EA\ : c rating score and the plasma level of free MHPG.3. Longitudinal study has been continued because of the application of autoregressive modelling for the analysis of the data.

本研究旨在探讨躁郁症hpa -轴和去甲肾上腺素能活性的时间生物学异常。比较5例双相情感障碍患者和10例正常对照者血浆皮质醇、血浆游离和总MHPG以及核心体温的昼夜节律。在患者组中，观察到血浆皮质醇的初相较早，血浆游离MHPG水平较低。其中1例患者在不同临床状态下反复检查。总MHPG水平在躁狂状态时较高，在抑郁状态时皮质醇的顶相较早。纵向研究5名双相患者和4名对照。每1-4周采集一次血样，持续约一年。测定血浆皮质醇、血浆游离量和总MHPG，并采用HRSD或13ea \: e躁狂症量表评估临床状态。患者组血浆皮质醇水平较低。各患者皮质醇水平变异系数较高。快速循环患者的mani13EA\: c评分与血浆游离MHPG.3水平有显著相关性。由于采用自回归模型对数据进行分析，因此纵向研究一直在继续。

项目成果

Uemura.H.et al: "Valproate and lithium in the combined treatment of a rapid cycling bipolar patient.Relationship to monoamine metabolites" Biological Psychiatry. 29. 345S-345S (1991)

Uemura.H.等人：“丙戊酸和锂联合治疗快速循环双相情感障碍患者。与单胺代谢物的关系”生物精神病学。

Mizuno,S.et al.: "A chronobiological study in a few affective disorder cases." Proceedings of the XXth International Congress of NeuroーVegitative Research. (1991)

Mizuno, S. 等人：“一些情感障碍病例的时间生物学研究。”第 20 届国际神经植物研究大会论文集（1991 年）。

Uemura, A.et al: "Diuanal rhythm of plasma total and free MHPG, plasma cortisol and body temperature." Japanese Journal of Psychiatry and Neurology. 44. 773-773 (1990)

Uemura, A.等人：“血浆总和游离 MHPG、血浆皮质醇和体温的昼夜节律。”

堀 宏治,他: "ヒト血漿MHPG値の日内変動" 自律神経. 27ー2. 206-206 (1990)

Koji Hori 等人：“人体血浆 MHPG 水平的昼夜变化”自主神经系统 27-206 (1990)。

上村秀樹: "ヒト血漿遊離および総MHPG値、コルチゾル値直腸温の日内変動" Japanese Journal of Psychiatry and Neurology.

Hideki Uemura：“人体血浆游离和总 MHPG 水平、皮质醇水平和直肠温度的昼夜变化”《日本精神病学和神经病学杂志》。