Chronobiological study on affective disorders using auto-regressive modelling. (Analysis of the relationship between HPA axis ans NA system)

本研究旨在探讨躁郁症hpa -轴和去甲肾上腺素能活性的时间生物学异常。比较5例双相情感障碍患者和10例正常对照者血浆皮质醇、血浆游离和总MHPG以及核心体温的昼夜节律。在患者组中，观察到血浆皮质醇的初相较早，血浆游离MHPG水平较低。其中1例患者在不同临床状态下反复检查。总MHPG水平在躁狂状态时较高，在抑郁状态时皮质醇的顶相较早。纵向研究5名双相患者和4名对照。每1-4周采集一次血样，持续约一年。测定血浆皮质醇、血浆游离量和总MHPG，并采用HRSD或13ea \: e躁狂症量表评估临床状态。患者组血浆皮质醇水平较低。各患者皮质醇水平变异系数较高。快速循环患者的mani13EA\: c评分与血浆游离MHPG.3水平有显著相关性。由于采用自回归模型对数据进行分析，因此纵向研究一直在继续。

The present study was designed to examine the chronobiological abnormalities of the HPA-axis and the noradrenergic activity in manic-depressive disorder.1. Circadian rhythms of plasma cortisol, plasma free and total MHPG, and core body temperature were compared in five bipolar patients and 10 normal controls. An earlier acrophase of plasma cortisol and a lower level of plasma free MHPG were observed13EA\ : in the patient group. One of the patients was examined repeatedly in different clinical states. The level of total MHPG was higher in a manic state and the acrophase of cortisol earlier in a depressive state.2. Five bipolar patients and four controls were studied longitudianally. Blood samples were obtained every 1-4 week for about a year. Plasma cortisol, plasma free and total MHPG were measured and the clinical state was estimated using the HRSD or th13EA\ : e manic rating scale of Petterson. In the patient group the level of plasma cortisol was lower. The coefficient of variation of cortisol level of each patient was higher. A patient with rapid-cycling showed a significant correlation between the mani13EA\ : c rating score and the plasma level of free MHPG.3. Longitudinal study has been continued because of the application of autoregressive modelling for the analysis of the data.