The "direct" effect of experimental subarachnoid hemorrhage on local cerebral metabolism and blood flow.

为了探讨蛛网膜下腔出血(SAH)对脑血流和代谢的“直接”影响，我们建立了一种新的大脑皮层SAH模型，利用该模型测定了大鼠局部脑葡萄糖利用率(LCGU)和局部脑血流量(LCBF)，并在SAH后2小时和48小时测量了LCGU和LCBF。LCGU变化：SAH后2小时患侧大脑皮质LCGU明显降低，至48小时仍有下降，但差异不显着。皮质下结构的LCGU保持不变。局部脑血流量变化：蛛网膜下腔出血后2小时患侧大脑皮质局部脑血流量也明显降低，提示蛛网膜下腔的新鲜血液对脑代谢和循环有直接影响。

To investigate the "direct" effects of subarachnoid hemorrhage (SAH) on cerebral blood flow and metabolism, we developed a new cortical SAH model in rat and measured local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) using it.LCGU and LCBF were measured at 2 hours and 48 hours after production to SAH.1. Change of LCGU : Cortical LCGU of the affected side 2 hours after SAH was significantly reduced and reduction of LCGU remained at 48 hours after SAH but was less significant. LCGU of subcortical structures remained unchanged.2. Change of LCBF : Cortical LCBF of the affected side 2 hours after SAH was also significantly reduced.These results show that fresh blood in the subarachnoid space has "direct" effect on cerebral metabolism and circulation.