The "direct" effect of experimental subarachnoid hemorrhage on local cerebral metabolism and blood flow.

实验性蛛网膜下腔出血对局部脑代谢和血流的“直接”影响。

• 批准号: 01570801
• 负责人: YAMAURA Akira
• 金额: $ 1.28万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570801/
• 关键词: subarachnoid hemorrhage; autoradiography; local cerebral glucose utilization; local cerebral blood flow; cerebral edema; cerebral dysfunction; 脳機能障害; ラット; autoradiography; 局所脳糖代謝率; 脳血流; 脳浮腫

To investigate the "direct" effects of subarachnoid hemorrhage (SAH) on cerebral blood flow and metabolism, we developed a new cortical SAH model in rat and measured local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) using it.LCGU and LCBF were measured at 2 hours and 48 hours after production to SAH.1. Change of LCGU : Cortical LCGU of the affected side 2 hours after SAH was significantly reduced and reduction of LCGU remained at 48 hours after SAH but was less significant. LCGU of subcortical structures remained unchanged.2. Change of LCBF : Cortical LCBF of the affected side 2 hours after SAH was also significantly reduced.These results show that fresh blood in the subarachnoid space has "direct" effect on cerebral metabolism and circulation.

为探讨蛛网膜下腔出血（subarachnoid hemorrhage，SAH）对脑血流量和代谢的“直接”影响，我们建立了一种新的大鼠皮层SAH模型，并在造模后2 h和48 h测定了局部脑葡萄糖利用率（LCGU）和局部脑血流量（LCBF）. LCGU变更：SAH后2h患侧皮质LCGU明显降低，48h LCGU仍有降低，但降低不明显。皮质下结构的LCGU保持不变. LCBF的变化：SAH后2h患侧皮层LCBF也明显降低，提示蛛网膜下腔新鲜血液对脑代谢和循环有“直接”作用。

项目成果

伊藤 千秋,他: "脳長くも膜下出血の脳グルコ-ス代謝におよぼす影響" 脳と神経. 43. 30-36 (1991)

Chiaki Ito 等：“长期脑膜下出血对脑葡萄糖代谢的影响”《大脑与神经》43. 30-36 (1991)。

Ito C. et. al: "The Effect of Cortical Subarachnoid Hemorrhage on Cerebral Glucose Metabolism." Brain and Nerve. 43 ・ 1. 30-36

Ito C. 等人：“皮质蛛网膜下腔出血对脑葡萄糖代谢的影响。” 43 ・ 1. 30-36

伊藤 千秋 他: "脳表くも膜下出血の脳グルコ-ス代謝におよぼす影響" 脳と神経. 43. 30-36 (1991)

Chiaki Ito 等人：“浅表蛛网膜下腔出血对脑葡萄糖代谢的影响”《大脑与神经》43. 30-36 (1991)。