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Develop in vivo PET imaging probes for ROCK2 as a biomarker of early Alzheimer's disease.

Develop in vivo PET imaging probes for ROCK2 as a biomarker of early Alzheimer's disease.
开发 ROCK2 的体内 PET 成像探针作为早期阿尔茨海默病的生物标志物。
批准号：
489145
负责人：
Zheng Chao
金额：
$55.45万
依托单位：
Centre for Addiction and Mental Health (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=489145&lang=en
关键词：
Alzheimer'S Disease Autoradiography Brain Penetrant Early Detection Pet Imaging Postmortem Human Brains Radiopharmaceuticals Rho-Associated Coiled-Coil Containing Protein Kinase 2 Rock2 Radioligands Synaptic Vesicle Glycoprotein 2a

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Alzheimer's disease (AD) and related dementia currently impact more than 747,000 Canadians and over 44 million people worldwide, exerting a tremendous socioeconomic burden on society. A one-year delay in dementia onset could prevent nearly 500,000 cases o
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