Cloning of Glicma Specific Tumor Supressor Gene

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Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma ( seven glioblastomas and two malignant astrocytomas ) was investigated. Loss of constitutional heterozygosity was found in four of the seven ( 57% ) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytoma cases. One glioblastoma case showed loss of constitutional heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed.