PATHOLOGICAL CLASSIFICATION AND CLINICAL SIGNIFICANCE OF BLADDER CANCER BASED ON MUTATION OF NUCLEAR ONCOGENE AND TUMOR SUPRESSOR GENE.

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We investigate the roles and possible interactions of retinoblastoma (RB), transforming growth factor-beta 1 (TGF-beta1) and c-myc genes in bladder cancer. The expression of these 3 genes was examined in 38 biopsy specimens of human bladder cancer by immunohistochemical study and Northern blotting. Loss of the retinoblastome protein expression was most significantly correlated with high grade cancer. Over expression of c-myc or expression of TGF-beta1 was less associated with tumor grade or stage, although c-myc over expression defined stage Ta against other stage tumors, since no stage Ta lesions had increased c-myc expression. Finally, loss of RB gene function did not correlate with either c-myc or TGF-beta1 expression.These results further support that RB gene inactivation is an important factor in the progression of bladder cancer, and suggest that TGF-beta1 and c-myc are not regulators or not regulated by RB gene expression.