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Development of Surgical Absorbable Implants Using Poly (lactic-acid

使用聚乳酸开发手术可吸收植入物

基本信息

批准号：
01870054
负责人：
SHIMISU Yasuhiko
金额：
$ 4.1万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B).
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Polylactide, polyglycolide and their copolymers are the synthetic polymers which are absorbed in the living tissue gradually with safe. The rate of absorption of each materials were detected to be the function of the factors of the materials characteristics such as : molecular weight, composition, crystallinity. Therefore the absorption rate are able to be controlled according to the clinical objections. Using these materials we have developed many types of surgical materials as following ; matrices for the drug delivery systems, surgical sutures, pledgets for suture reinforcement, bolster, hemostat, patch seat for soft tissue defects, anti-adhesion sheets, bone connective pins, struts for chest deformity. The in vivo implantation tests using animals showed their clinical security and applicability. Some of them have been now used clinically.Adriamycin-Containing poly (L-Lactic Acid) Microspheres have been used clinically and their effectiveness for pleural effusion caused by the lung cancer was reported on the journal of DDS (vol. 5.1990).Monofilament suture made from polymer of lactic acid and caprolactone have been developed. This suture is absorbed in the body more slowly than the conventional absorbable sutures which supposed to be available for vascular surgery.Pledgets, bolster and suture reinforcement made from Polyglycolide are now widely used and their clinical availability and excellent effectiveness were reported on the journal of the Thoracic Cardiovascular Surgeon (vol. 38.1990).

聚丙交酯、聚乙交酯及其共聚物是人工合成的高分子材料，在生物组织中吸收缓慢，安全性高。每种材料的吸收速率被检测为材料特性的因素的函数，如：分子量，组成，结晶度。因此，能够根据临床目标控制吸收率。利用这些材料，我们开发了多种类型的手术材料，如下所示：药物输送系统基质、手术缝线、缝线加固垫片、软垫、止血剂、软组织缺损修补座、防粘连片、骨连接针、胸部畸形支柱。动物体内植入试验表明其临床安全性和适用性。其中一部分已应用于临床，阿霉素聚乳酸微球已应用于临床，DDS杂志（Vol.5.1990）报道了其治疗肺癌引起的胸腔积液的有效性，已开发出由乳酸和己内酯聚合物制成的单丝缝线。这种缝线在体内的吸收速度比传统的可吸收缝线慢，而传统的可吸收缝线被认为可用于血管外科手术。聚乙交酯制成的垫片、支撑物和缝线加固物现在被广泛使用，其临床可用性和优异的有效性已在《胸心血管外科医生》杂志（第38卷，1990年）上报道。