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Development of Surgical Absorbable Implants Using Poly (lactic-acid

使用聚乳酸开发手术可吸收植入物

基本信息

批准号：
01870054
负责人：
SHIMISU Yasuhiko
金额：
$ 4.1万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B).
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Polylactide, polyglycolide and their copolymers are the synthetic polymers which are absorbed in the living tissue gradually with safe. The rate of absorption of each materials were detected to be the function of the factors of the materials characteristics such as : molecular weight, composition, crystallinity. Therefore the absorption rate are able to be controlled according to the clinical objections. Using these materials we have developed many types of surgical materials as following ; matrices for the drug delivery systems, surgical sutures, pledgets for suture reinforcement, bolster, hemostat, patch seat for soft tissue defects, anti-adhesion sheets, bone connective pins, struts for chest deformity. The in vivo implantation tests using animals showed their clinical security and applicability. Some of them have been now used clinically.Adriamycin-Containing poly (L-Lactic Acid) Microspheres have been used clinically and their effectiveness for pleural effusion caused by the lung cancer was reported on the journal of DDS (vol. 5.1990).Monofilament suture made from polymer of lactic acid and caprolactone have been developed. This suture is absorbed in the body more slowly than the conventional absorbable sutures which supposed to be available for vascular surgery.Pledgets, bolster and suture reinforcement made from Polyglycolide are now widely used and their clinical availability and excellent effectiveness were reported on the journal of the Thoracic Cardiovascular Surgeon (vol. 38.1990).

聚丙交酯、聚乙二醇酯及其共聚物是一种可安全、逐渐被活体组织吸收的人工合成聚合物。每种材料的吸收率是材料特性因素的函数，如：分子量、组成、结晶度。因此，吸收率可以根据临床需要进行控制。利用这些材料，我们开发了许多类型的手术材料如下：用于药物输送系统的基质、外科缝合线、缝合线加固用的衬垫、支撑、止血器、用于软组织缺损的贴片座、抗粘连片、骨连接针、用于胸部畸形的支柱。动物体内植入试验证明了其临床安全性和适用性。其中一些已经被用于临床。含阿霉素聚l -乳酸微球已用于临床，其治疗肺癌所致胸腔积液的疗效已在《美国临床医学杂志》1990年第5期报道。以乳酸和己内酯为原料制备了单丝缝合线。这种缝合线被人体吸收的速度比传统的可吸收缝合线要慢，而传统的可吸收缝合线通常用于血管手术。由聚甘油内酯制成的衬垫、枕垫和缝线加强物现已广泛使用，《胸心血管外科杂志》（1990年第38卷）报道了它们的临床可用性和极好的疗效。