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Development of Surgical Absorbable Implants Using Poly (lactic-acid

使用聚乳酸开发手术可吸收植入物

基本信息

批准号：
01870054
负责人：
SHIMISU Yasuhiko
金额：
$ 4.1万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B).
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

Polylactide, polyglycolide and their copolymers are the synthetic polymers which are absorbed in the living tissue gradually with safe. The rate of absorption of each materials were detected to be the function of the factors of the materials characteristics such as : molecular weight, composition, crystallinity. Therefore the absorption rate are able to be controlled according to the clinical objections. Using these materials we have developed many types of surgical materials as following ; matrices for the drug delivery systems, surgical sutures, pledgets for suture reinforcement, bolster, hemostat, patch seat for soft tissue defects, anti-adhesion sheets, bone connective pins, struts for chest deformity. The in vivo implantation tests using animals showed their clinical security and applicability. Some of them have been now used clinically.Adriamycin-Containing poly (L-Lactic Acid) Microspheres have been used clinically and their effectiveness for pleural effusion caused by the lung cancer was reported on the journal of DDS (vol. 5.1990).Monofilament suture made from polymer of lactic acid and caprolactone have been developed. This suture is absorbed in the body more slowly than the conventional absorbable sutures which supposed to be available for vascular surgery.Pledgets, bolster and suture reinforcement made from Polyglycolide are now widely used and their clinical availability and excellent effectiveness were reported on the journal of the Thoracic Cardiovascular Surgeon (vol. 38.1990).

聚丙交酯、聚乙交酯及其共聚物是逐渐被生物组织吸收且安全的合成聚合物。检测到每种材料的吸收率是材料特性因素的函数，例如：分子量、组成、结晶度。因此可以根据临床目的控制吸收率。利用这些材料，我们开发了以下多种类型的手术材料；药物输送系统基质、手术缝合线、缝合加固垫片、垫枕、止血钳、软组织缺损补片座、防粘连片、骨连接销、胸部畸形支柱。动物体内植入试验显示了其临床安全性和适用性。其中一些现已应用于临床。含阿霉素的聚(L-乳酸)微球已应用于临床，其治疗肺癌引起的胸腔积液的有效性已在DDS杂志(vol.5.1990)上报道。由乳酸和己内酯聚合物制成的单丝缝合线已开发出来。这种缝线在体内的吸收速度比血管手术中使用的传统可吸收缝线慢。由聚乙交酯制成的垫片、垫枕和缝线加固材料现已广泛使用，其临床可用性和优异的有效性在胸心血管外科医生杂志（第 38.1990 卷）上进行了报道。