Hypertonic saline for acute cerebral swelling following multiple trauma with severe head injury.

高渗盐水用于治疗多发性严重颅脑损伤后的急性脑肿胀。

• 批准号: 02404051
• 负责人: SHIMAZAKI Shuji
• 金额: $ 1.92万
• 依托单位: KYOURIN UNIV.SCHOOL OF MEDICINE.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404051/
• 关键词: Intracerebral pressure; Cerebral perfusion pressure; Hypertonic saline; Multiple trauma; 高張ナトリウム輸液; 抗脳浮腫効果

The system which we have established is as followed ; measuring the pressure with digital pressure catheter (model 110-4E) and chnage it into electric signals (by model 420). Amplified the signals (by AG-601G) and record them on thermal recorder (PAT-1200). Also the signals will be integrated (by EI-601G) and stored them in a floppy disk. Simultaneously, data of arterial blood pressure will be processed in a same way and integrated cerebral perfusion pressure will be calculated and stored them in a floppy disk. In 1990, basic masureing system were established. In 1991, most of efforts were shared to obtain an optimal time constant for measurement of integrated pressure. Patients with multiple trauma have variety of pulse rate (150-50/min.) and it changes quite rapidly. Initially time constant was set at 1 sec. with this time constant for standadized the data, data fluctuation was occured. Time constant 3, 5, 8, 10 have been evaluated and 3 second was the best time constant for this data processing system. Obtaining this value the final system and its program was established.According to this research project, the system by which we can eveluate pressure effect across time on brain becomes avaiable. We would be able to apply the system to clinical cases as we have planed in the initial 4 years schedule.

我们建立的系统是：用数字压力导管（110- 4 E型）测量压力，并将其转换成电信号（420型）。放大信号（通过AG-601 G）并将其记录在热记录仪（PAT-1200）上。此外，信号将被集成（由EI-601 G），并将其存储在软盘中。同时，动脉血压数据将以相同的方式处理，并计算出积分脑灌注压，并将其存储在软盘中。1990年，建立了基本的测量系统。在1991年，大部分的努力是共同获得一个最佳的时间常数测量的综合压力。多发伤患者的脉率变化范围较大（150-50次/min）。而且变化很快最初时间常数设定为1秒。用这个时间常数对数据进行标准化处理，会出现数据波动。对时间常数3、5、8、10进行了评价，认为3秒是本数据处理系统的最佳时间常数。在此基础上，建立了一套完整的脑电压力测量系统，并编制了相应的软件，实现了对脑电压力随时间变化的测量。我们将能够按照最初4年的计划将该系统应用于临床病例。