Hypertonic saline for acute cerebral swelling following multiple trauma with severe head injury.

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The system which we have established is as followed ; measuring the pressure with digital pressure catheter (model 110-4E) and chnage it into electric signals (by model 420). Amplified the signals (by AG-601G) and record them on thermal recorder (PAT-1200). Also the signals will be integrated (by EI-601G) and stored them in a floppy disk. Simultaneously, data of arterial blood pressure will be processed in a same way and integrated cerebral perfusion pressure will be calculated and stored them in a floppy disk. In 1990, basic masureing system were established. In 1991, most of efforts were shared to obtain an optimal time constant for measurement of integrated pressure. Patients with multiple trauma have variety of pulse rate (150-50/min.) and it changes quite rapidly. Initially time constant was set at 1 sec. with this time constant for standadized the data, data fluctuation was occured. Time constant 3, 5, 8, 10 have been evaluated and 3 second was the best time constant for this data processing system. Obtaining this value the final system and its program was established.According to this research project, the system by which we can eveluate pressure effect across time on brain becomes avaiable. We would be able to apply the system to clinical cases as we have planed in the initial 4 years schedule.