Research on the etiology and the mechanism of progression for spondylosis.

脊柱病的病因及进展机制研究。

• 批准号: 02404059
• 负责人: ONO Keiro
• 金额: $ 6.46万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404059/
• 关键词: Spondylosis; Disc Degeneration; Osteophyte; Fatigue; Mechanical Environment; Motion Analysis; Instability; Athetoid Cerebral Palsy; 繰り返し負荷; 構造破綻; 外科的治療; 椎間関節; 腰椎分離症; ねじり負荷; 脊柱不安定性; 破壊テスト; 頸椎症; 疲労現像; せん断力; 曲げモ-メント

For the purpose to clarify the etiology and the mechanism of progression of spondylosis, basic and clinical researches were performed. Their results were as follows ;1) Radiographic examination of the cervical spine demonstrated that early onset and rapid progression of spondylosis occurred in patients with athetoid cerebral palsy. Therefore, their cervical spine could be regarded as a good material for understanding the pathogenesis of spondylosis, especially from the biomechanical viewpoint.2) Motion analysis of the cervical spine showed the kinematic abnormality in patients with athetoid cerebral palsy. The correlation between its abnormality and premature onset of spondylosis was demonstrated by simple simulation model.3) Tensile stiffness of a lumbar motion segment was measured intraoperatively. The mechanical effect of disc degeneration and surgical decompression was demonstrated from its measurement.4) The effect of repetitive movement on the spine was evaluated in vivo and in v … More itro by using Japanese white rabbits. Repetitive loading caused the spondylotic change in vivo and mechanical weakening of the motion segment in vitro. These results suggest that overuse or fatigue is an important factor in the pathogenesis of spondylosis.5) Surgical results for myelopathy and radiculopathy in patients with athetoid cerebral palsy were evaluated. Based on these results, surgical planning for them was presented.6) Radiographic examination of the lumbar spine demonstrated that the incidence of spondylolysis was higher in patients with spastic diplegia than normal control. Its pathogenesis was discussed.In conclusion, spondylosis is thought to be associated with not only aging, but also mechanical environment. Further studies are necessary to clarify many unsolved problems, which are, for example, the relation between type of loading and spine response, mechanical effects on cells and tissues of the spine, etc. On the other hand, clinical materials from this research will give us more information for natural course of the disease and the better treatment by further follow-up. Less

为了阐明颈椎病的病因和进展机制，进行了基础和临床研究。结果表明：1）手足徐动型脑性瘫痪患者颈椎X线检查显示颈椎病发病早，进展快。因此，从生物力学的角度，颈椎可作为了解椎关节病发病机制的良好材料。2）运动学分析显示手足徐动型脑瘫患者颈椎存在运动学异常。通过简单的模拟模型，证实了其异常与过早发病的相关性。3）术中测量腰椎运动节段的拉伸刚度。4）在活体和活体动物模型上评价了重复运动对脊柱的影响，并对重复运动对脊柱的影响进行了评价。 ...更多信息 用日本白色家兔离体培养。在体内，重复载荷引起脊柱的变化，在体外，运动节段的力学减弱。这些结果表明，过度使用或疲劳是脊椎病发病机制中的一个重要因素。5）评估手足徐动型脑瘫患者脊髓病和神经根病的手术结果。6）腰椎X线检查显示痉挛型双瘫患者椎弓峡部裂的发生率高于正常对照组。结论：颈椎病不仅与年龄有关，而且与机械环境有关。需要进一步的研究来澄清许多未解决的问题，例如，载荷类型与脊柱反应之间的关系，对脊柱细胞和组织的力学效应等。另一方面，本研究的临床资料将为我们提供更多的信息，为疾病的自然病程和更好的治疗提供进一步的随访。少

项目成果

T.Harada: "The Lumbar Spine in Spastic Diplegia." The Journal of Bone and Joint Surgery.75-B. 534-537 (1993)

T.Harada：“痉挛性截瘫中的腰椎。”

S.Ebara, T.Harada, N.Hosono, M.Inoue, M.Tanaka, Y.Morimoto and K.Ono: "Intraoperative Measurement of Lumbar Spinal Instability." Spine. 17. S44-S50 (1992)

S.Ebara、T.Harada、N.Hosono、M.Inoue、M.Tanaka、Y.Morimoto 和 K.Ono：“腰椎不稳定性的术中测量”。

原田武雄: "アセトーゼ型脳性麻痺患者に生じる頸椎症性神経根症、頸髄症に対する手術治療" 中部日本整形災害外科学会誌. 37(発表予定). (1994)

原田武夫：“醋酸性脑瘫患者的神经根型颈椎病和脊髓型颈椎病的手术治疗”日本中部整形外科学会杂志37（待出版）。

江原 宗平,小野 啓郎,他: "生体工学からみた組織の変性と修復" BME. 6. 26-30 (1992)

Sohei Ehara、Keiro Ono 等人：“从生物工程的角度来看组织退化和修复”BME 6. 26-30 (1992)。

Eiji Wada,Sohei Ebara,et al: "Experimental Study of Cervical Facet Degeneration in Rabbits" Transactions of the39th Annual Meeting,Orthopaedic Research Society. 18. 409 (1993)

Eiji Wada，Sohei Ebara，等：“兔子颈椎小面退化的实验研究”第39届骨科研究会年会会刊。