Role of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in sperm maturation

磷脂氢过氧化物谷胱甘肽过氧化物酶 (PHGPx) 在精子成熟中的作用

• 批准号: 5238476
• 负责人: Professor Dr. Leopold Flohé
• 金额: --
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2000
• 资助国家: 德国
• 起止时间: 1999-12-31 至 2006-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5238476?language=en
• 关键词: Role; phospholipid; hydroperoxide; glutathione; peroxidase

The relationship between PHGPx content of sperm and male fertility is to be investigated in humans and experimental animals. The process leading to a transformation of the soluble peroxidase PHGPx in spermatids to an enzymatically inactive structural protein in mature spermatozoa is to be investigated by analytical chemistry and molecular biology techniques. Of particular interest are/i) the catalysts and/or co-reactants contributing to the transformation of PHGPx,ii) the source and nature of the oxidants required, and/iii) the triggering mechanisms underlying this differentiation process.

精子中PHGPx含量与男性生育能力的关系有待于在人类和实验动物中研究。精子中可溶性过氧化物酶PHGPx转化为成熟精子中酶活性结构蛋白的过程将通过分析化学和分子生物学技术进行研究。特别感兴趣的是/i)促进PHGPx转化的催化剂和/或共反应物，ii)所需氧化剂的来源和性质，以及/iii)这一分化过程的触发机制。