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Measurement of Microbubbles in Pulsating Blood by Razer Bubble Detector

Razer 气泡探测器测量脉动血液中的微气泡

基本信息

批准号：
02805023
负责人：
TSUJINO Tomoji
金额：
$ 0.7万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02805023/
关键词：
Vibration injury Raynaud's phenomenon Bubble Blood Pulsating blood flow Biomechanics

项目摘要

Vibration injuries are occupational diseases with disturbances of peripheral circulation, which are brought on when vibration is transmitted to human body from vibratory tools and niachines. It is very important to clarify the mechanism about the attach of this disease because of the protection of disturbance and the establishment of radical cure. There has been only a little amount of information about the fundamental mechanism. In particular, the biomechanical study is urgently needed. The purposes of this work are to detect gas bubbles in blood subjected to a pulsation, to make clear experimentally thO condition of bubble generation, and to find theoretically the bubble behavior in blood. A decompressive and vibratory apparatus of bubble generation is made, which is possessed of the experimental conditions about the depressorization DELTAP=0-650mmHg, the vibratory frequency f=0-40Hz, and the amplitude A=4mm. The tested liquids are dogs'blood, in addition to, isotonic sodium chloride solution, tap water, and oil, for comparison. The following matters are found from the experimental results. It is easy to generate bubbles in pulsating blood, as compared with the other tested liquids. An increase of vibratory frequency is promoted the formation of bubbles. Under the condition of atmospheric pressure, the bubbles generate in blood when the frequency is greater than 28Hz. The diameters of bubbles are about 0.2mm. It is clear from the theoretical study of bubble motion that the impulsive pressure occurs when the bubble oscillates with non-linear resonance in blood. The generated pressure is small with a decrement of hematocrit, and is large with an increment of bubble size.

振动损伤是一种外周循环障碍的职业病，是振动从振动工具和机械传递到人体时引起的。阐明该病的发病机制，对于防治干扰，建立根治性治疗方法具有重要意义。关于基本机制的信息一直很少。尤其是生物力学研究迫在眉睫。本工作的目的是探测脉动下血液中的气泡，从实验上弄清气泡产生的条件，并从理论上发现血液中的气泡行为。研制了减压振动式气泡产生装置，其实验条件为：降压深度DELTAP=0-650 mm，振动频率f=0-40 Hz，振幅A=4 mm。被测试的液体是狗的血液，此外还有等渗氯化钠溶液、自来水和油，以供比较。从实验结果中发现了以下几个问题。与其他被测试的液体相比，在脉动的血液中很容易产生气泡。振动频率的提高促进了气泡的形成。在大气压条件下，当频率大于28赫兹时，血液中就会产生气泡。气泡的直径约为0.2 mm。从气泡运动的理论研究可以看出，当气泡在血液中以非线性共振方式振荡时，就会产生冲击压力。产生的压力随着红细胞压积的降低而减小，随着气泡尺寸的增大而增大。