Study of Bubble Nuclei Distribution and Bubble Embolism in Plasma Subjected with Variation of Environmental Pressure

环境压力变化下血浆中气泡核分布和气泡栓塞的研究

• 批准号: 09650199
• 负责人: TSUJINO Tomoji
• 金额: $ 1.98万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650199/
• 关键词: Fluid Mechanics; Bioengineering; Bubble; Bubble Nuclei; Gas Diffusion; Bubble Embolism; Decompression Disease; Submarine Sickness; 気泡寒栓; 人工弁; 血管閉塞; ヘリウムガス; 血漿

It is understood that the gases dissolved in human body under the condition of high pressure produced the bubbles in blood vessels as coming back to the atmosphere from an environment of high pressure, and that decompression disease causes disturbances of peripheral circulation due to bubble embolism. However very little is known about the mechanism.In the present study, as the purpose of clarification of mechanism of an outbreak of decompression disease, the distributions of the bubble nuclei in liquids subjected with the variation of pressure are made clear by the coulter counter method. Test liquids are water, plasma and blood. Test gases are air, carbon dioxide gas, oxygen gas and helium gas.Consequently, it is found that the bubble nuclei with diameter more than 10μ m increase with an increment of the additional gas pressure. The number of bubble nuclei of carbon dioxide gas is the most in the other gases. The nuclei number of helium gas is the least. The number of bubble nuclei in plasma is larger than in water. In blood, the number of bubble nuclei with comparatively large size increases compared with that in water. The number of bubble nuclei in flowing liquids increase more than 1〜4 order of magnitude than the static condition, and the nuclei number increases with an increment of flow velocity. The mechanism of bubble embolism which causes decompression disease is clarified.

据了解，在高压条件下溶解在人体内的气体从高压环境返回大气时在血管中产生气泡，并且减压病由于气泡栓塞而引起外周循环障碍。为了阐明减压病暴发的机理，本文采用库尔特计数器法，研究了减压病暴发时液体中气泡核随压力变化的分布规律。试验液体为水、血浆和血液。实验气体为空气、二氧化碳、氧气和氦气，实验结果表明，随着附加气体压力的增加，直径大于10μ m的气泡核数增加。二氧化碳气体的气泡核数是其他气体中最多的。氦气的原子核数最少。等离子体中气泡核的数量比水中的多。在血液中，与在水中相比，具有较大尺寸的气泡核的数量增加。流动液体中的气泡核数比静止条件下增加1 × 10 - 4数量级以上，且随着流速的增加而增加。阐明了气泡栓塞引起减压病的机理。

项目成果

T. Tsujino: "Dissolution of NィイD22ィエD2Bubbles in Blood under Hyperbaric Oxygen Therapy"Memoirs of The Faculty of Education, Kumamoto Univeristy. 47. 81-86 (1998)

T. Tsujino：“高压氧治疗下血液中 D22 气泡的溶解”熊本大学教育学院回忆录 47. 81-86 (1998)。

K. Uranishi, T. Tsujino, M. Miura: "Development of a Micro Turbo Pump"Proc. Of JSME Caternial Grand Cong. Inter. Conf. Fluid Eng..

K. Uranishi、T. Tsujino、M. Miura：“微型涡轮泵的开发”Proc。

K. Uranishi and T. Tsujino: "Development of a Micro Turbo Pump"Proc. of JSME Ceternial Grand Cong. Inter. Conf. Fluid Engng.. 857-862 (1997)

K. Uranishi 和 T. Tsujino：“微型涡轮泵的开发”Proc。

K.Uranishi, T.Tsujino. M.Miura: "Development of a Micro Turbo Pump" Proc.of JSME Ceternicl Grand Cong.Inter.Conf.Fluid Engng. 857-862 (1997)

K.Uranishi，T.Tsujino。

辻野智二、塚本光夫、堀光晴: "ガス過飽和液流における発泡現象に関する研究"キャビテーションに関するシンポジウムプロシーディングス. 9. 103-106 (1997)

Tomoji Tsujino、Mitsuo Tsukamoto、Mitsuharu Hori：“气体过饱和液体流动中的泡沫现象研究”空化研讨会论文集。 9. 103-106 (1997)