Relationship between Gastrointestinal Myoelctric Activity and Portal Venous Flow before and after Truncal Vagotomy, Gastrectomy with or without Vagotomy.

迷走神经干切断术、胃切除术伴或不伴迷走神经切断术前后胃肠肌电活动与门静脉流量的关系。

• 批准号: 02807118
• 负责人: MATSUO Hitoshi
• 金额: $ 0.96万
• 依托单位: First Department of Surgery, Niigata University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807118/
• 关键词: Gastrectomy; Truncal Vagotomy; Gastrointestinal Motility; Portal Venous Flow; Solid Meal; Liquid Meal; 固型食; 空腹期強収縮波群

During the fasting, gastrointestinal tract showed periodic activity, and the migrating myoelectric complex (MMC) occurred regularly in the stomach and the duodenum, and propagated distally. Feeding dramatically disrupted MMCs, then uniform electrical activity of the fed pattern took place in the entire intestine.The fasting portal venous flow (PVF) showed slight fluctuation, according to the gastroduodenal activity. Postprandial changes in PVF were closely correlated with intestinal activity. After ingestion of meal, PVF soon elevated and reached plateau within 30min. Period of increased PVF persisted for more than 2 hours, then the PVF gradually decreased to the fasting value.There was significant correlation between the time required for reappearance of MMC in the upper jejunum (MMC-inhibition time) and the PVF-increasing time (<mean fasting PVF + 2SD).After truncal vagotomy (TV), periodic appearance of MMCs ws observed in the small intestine, while few MMCs occurred in the stomach even after 24-h fasting. Feeding abolished MMCs from the intestine, converting the fasting pattern to the feeding pattern.After TV, changes in PVF after feeding showed a various patterns. Some postprandial PVF increased rapidly, while another very slowly.Both MMC-inhibition time and PVF-increasing time varied in each day and between dogs. The correlation between MMC-inhibition time and PVF-increasing time was not seen after TV.In conclusion, motility disorders after vagotomy influence on intestinal circulation, causing a disturbed portal blood supply to the liver.To clarify the effects of distal partial gastrectomy with or without vagotomy on intestinal motility and circulation, Further studies on the intestinal myoelectric activity and PVF will be required.

禁食期间胃肠道呈周期性活动，移行性复合肌电（MMC）在胃和十二指肠有规律地发生，并向远端传播。进食使MMCs明显受损，整个肠道出现均匀的进食模式电活动，空腹门静脉血流量（PVF）随胃十二指肠活动而略有波动。餐后PVF的变化与肠道活动密切相关。进食后，PVF迅速升高，并在30 min内达到平台。PVF升高持续时间大于2 h后，PVF逐渐下降至空腹值，空肠上段MMC恢复所需时间与PVF升高时间呈显著正相关（MMC-抑制时间）和PVF-增加时间（<平均空腹PVF + 2SD）。迷走神经干切断术（TV）后，在小肠中观察到周期性出现MMC，禁食24 h后胃内仍有少量MMCs出现。喂食可使肠道内MMCs消失，使禁食模式转变为喂食模式。餐后PVF有的迅速增加，有的缓慢增加，MMC抑制时间和PVF增加时间在每天和犬间均不同。结论：迷走神经切断术后肠动力障碍影响肠循环，导致门静脉血供紊乱，为了明确远端胃部分切除术后肠动力和肠循环的影响，需要进一步研究肠肌电活动和PVF。

项目成果

佐藤 賢治,松尾 仁之,島影 尚弘,小野 一之,松原 要一,武藤 輝一: "空腹期および流動食投与下における消化管筋電図と門脈血流量に関する実験的研究ー迷走神経切離術前後の比較ー" 日本平滑筋学会雑誌. 26(6). 451-453 (1990)

Kenji Sato、Hiroyuki Matsuo、Naohiro Shimakage、Kazuyuki Ono、Yoichi Matsubara、Keiichi Muto：“禁食期间和流质饮食给药下胃肠道肌电图和门静脉血流的实验研究 - 迷走神经切断术”前后比较”日本平滑杂志肌肉协会。26（6）。451-453（1990）。

Sato, K., Matsuo, H., Shimakage, N., Ono, K., Takeda, N., Tamiya, Y., Matsubara, Y., and Muto, T.: "Relationship between gastrointestinal myoelectric activity and portal venous flow before and after trucal vagotomy." Jpn. J. Smooth Muscle Res.27.

Sato, K.、Matsuo, H.、Shimakage, N.、Ono, K.、Takeda, N.、Tamiya, Y.、Matsubara, Y. 和 Muto, T.：“胃肠道肌电活动与门静脉之间的关系

佐藤 賢治,松尾 仁之,島影 尚弘,小野 一之,武田 信夫,田宮 洋一,松原 要一,武藤 輝一: "迷走神経切離術が門脈血流量および消化管運動に及ぼす影響に関する実験的研究" 日本平滑筋学会雑誌. (1992)

Kenji Sato、Hiroyuki Matsuo、Naohiro Shimakage、Kazuyuki Ono、Nobuo Takeda、Yoichi Tamiya、Yoichi Matsubara、Teruichi Muto：“迷走神经切断术对门脉血流和胃肠动力影响的实验研究”日本平滑肌学会杂志（1992 年）。 ）