Role of Endocrine Systems on Changes of Kidney Function during Aging

衰老过程中内分泌系统对肾功能变化的作用

• 批准号: 02640581
• 负责人: KOBAYASHI Yuta
• 金额: $ 1.22万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02640581/
• 关键词: Aging; Water-electrolyte metabolism; Kidney; Calcium Metabolism; Osteoporosis; Atrial Natriuretic peptide; Wister; Tw rats; NOD mice; アルドステロン; 血漿レニン活性; 大腿骨; カルシトニン; 性ホルモン; 水・電解質代謝; カルシウム; Wister; Tw; パラトルモン; 糖尿病マウス

Wistar/Tw strain male rats show polydipsia and polyuria after 16 months of age, while after 20 months of age in female rats. Current studies have suggested that this strain is a model for accelerated aging in water and electrolyte metabolism and kidney function, which are important for the control of homeostasis of animals. In the present study, age-related changes of kidney function and role of endocrine systems on the changes were investigated using this substrain rats.1. Kidney function during aging was studied and age-related increases of serum phospholipids and triglyceride were observed in female rats. These changes are considered to agree with the changes of serum parameters with dysfunction of kidney in human. 2. No significant change on serum atrial natriuretic peptide(ANP)concentration was observed during aging of this strain. Changes on ANP with the occurrence of diabetes mellitus were studied using non-obese diabetic(NOD)mice, as the diabetes mellitus animals also show poly … More dipsia. Significant reduction of serum ANP concentration and significant enhancement of atrial ANP content were observed. 3. Reduction of serum aldosterone concentration and plasma renin activity(1 to 10 fold)during aging of Wistar/Tw strain was observed. These results may be explained by the reduction of release of renin with the pathological changes of kidney. Increase of serum vasopressin concentration during aging has reported. Thus, changes of serum hormones which related to water and electrolyte metabolism have clarified in this substrain. 4. Furthermore, marked increase(10 fold)of urinary excretion of calcium in 24 hours with aging of female rats was found. 5. Reduction of bone materials in X-ray photograph, significant reductions of dry weight and calcium content in the femur, significant reductions of dry weight and mechanical strength of tail vertebrae were observed. These changes suggest that this female rats may be a model rat for spontaneous osteoporosis. 6. Serum calcitonin concentration showed no significant change.Further studies are necessary to clarify the mechanism of such changes in calcium metabolism during aging. Less

Wistar/TW菌株雄性大鼠在16个月大后出现多次多皮亚和多尿症，而在女性大鼠20个月后，则表现出多尿和多尿。当前的研究表明，这种菌株是水和电解质代谢和肾功能加速衰老的模型，这对于控制动物体内稳态很重要。在本研究中，使用此基质大鼠研究了肾功能与年龄相关的变化以及内分泌系统在变化上的作用。1。在衰老过程中进行肾功能，并在雌性大鼠中观察到与年龄相关的血清磷脂和甘油三酸酯的增加。这些变化被认为与人类肾功能障碍的血清参数变化一致。 2。在该菌株衰老期间，没有观察到血清心房纳他肽（ANP）浓度的显着变化。随着糖尿病的发生，ANP的变化使用非肥胖糖尿病（NOD）小鼠进行了研究，因为糖尿病动物也显示出多次dipsia。观察到了血清ANP浓度的显着降低和心房ANP含量的显着增强。 3。在Wistar/TW菌株衰老期间，血清醛固酮浓度和血浆肾素活性（1至10倍）的降低。这些结果可以通过减少肾脏变化的肾素释放来解释。据报道，衰老过程中连续加压素浓度的增加。这是在该基质中阐明的与水和电解质代谢相关的血清马的变化。 4.此外，发现雌性大鼠衰老的24小时内明显增加（10倍）的尿液极端钙的增加（10倍）。 5。X射线照片中的骨料减少，股骨干重和钙含量的显着减少，观察到尾椎骨的干重和机械强度的显着降低。这些变化表明，该雌性大鼠可能是赞助骨质疏松症的模型大鼠。 6。血清降钙素浓度没有明显的变化。为阐明衰老过程中钙代谢变化的机制是必要的。较少的

项目成果

Shuichi Yano: "Atrial natriuretic peptide (ANP) levels in plasma and atrial auricles of the nonーobese diabetic (NOD) mouse In: Diabetic Heart" Kluwer Academic Publishers eds by M.Nagano and S.Mochizuki, 17

Shuichi Yano：“非肥胖糖尿病 (NOD) 小鼠血浆和心房心房中的心钠素 (ANP) 水平：糖尿病心脏”，M.Nagano 和 S.Mochizuki 编着的 Kluwer 学术出版社，17

Yano, Shuichi et al.: "Effect of diabetes mellitus on level of atrial natriuretic hormone in plasma and the right atrium in the non-obese diabetic mouse." Acta Endocrinol. (Copenh). 124. 595-601 (1991)

Yano、Shuichi 等人：“糖尿病对非肥胖糖尿病小鼠血浆和右心房心钠素水平的影响。”

Mifune, Hiroharu et al.: "Atrial natriuretic peptide (ANP) : a study of ANP and its mRNA in cardiocytes, and of plasma ANP levels in non-obese diabetic mice." Cell Tissue Res. 267. 267-272 (1992)

Mifune、Hiroharu 等人：“心房钠尿肽 (ANP)：对心肌细胞中 ANP 及其 mRNA 以及非肥胖糖尿病小鼠血浆 ANP 水平的研究。”

Shuichi Yano: "Effects of diabetes mellitus on levels of atrial natriuretic hormon (ANP) in plasma and the right atrium in the nonーobese diabetic (NOD) mouse" Acta Endocrinologica.

Shuichi Yano：“糖尿病对非肥胖糖尿病 (NOD) 小鼠血浆和右心房心钠素 (ANP) 水平的影响”《内分泌学报》。

Mifune,Hiroharu: "Atrial natriuretic peptide (ANP):a study of ANP and its mRNA in cardiocytes,and of plasma ANP levels in non-obese diabetic mice." Cell Tissue Res.267. 267-272 (1992)

Mifune、Hiroharu：“心房钠尿肽 (ANP)：对心肌细胞中 ANP 及其 mRNA 以及非肥胖糖尿病小鼠血浆 ANP 水平的研究。”