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Development of Heat Generating Magnetic Materials for Hyperthermia and Application to Medical Treatment

热疗用磁性发热材料的研制及其在医疗中的应用

基本信息

批准号：
02559008
负责人：
MATSUI Masaaki
金额：
$ 9.02万
依托单位：
Nagoya university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02559008/
关键词：
Interstitial heating hyperthermia heat generating materials Fe-Pt alloys Mg-Ca Ferrites Silane-coating eddy current loss hysteresis loss フェライトガラスコ-ティング FeーPt合金溶出試験

项目摘要

The implant materials for hyperthermia of cancer tissues were developed and the clinical investigations were performed. Results of the research are summarized as follows :1. The corrosion resistance of the Fe-Pt alloy implant material for hyperthermia, which has low Curie point and large heat generation through the eddy current loss, is larger than that of a stainless steel. However, when the implant was embedded in the tissue of the thigh of a rabbit, the dissolved Fe element was a little bit detected in the X-ray analysis(1.0 x 10^<-4> g/cm^2 month).2. In order to prevent the alloy elements from dissolving, the biocompatible compound SiO_2 was coated on the implant using silane and phosphorus acid. The coating improved the corrosion resistance remarkably.3. The powder samples of Fe-Pt alloys were prepared as a heat generation materials through magnetic hysteresis loss. The heat generation of the powder material was enough to be used for hyperthermia. A spray-drying method was developed for the SiO_2 coating of the powder particles.4. The ceramic materials of CaO-MgO-Fe_2O_3 system whose elements are all biocompatible were investigated as new powder implant materials for hyperthermia. It was found that the materials of x=0.525 for (MgO)_<1-x>(Fe_2O_3)_x and y=1.0 for (CaFe_4O_7)_<1-y>(MgFe_2O_4)_y have the large heat generation through hysteresis loss which is several times larger than that of Fe_3O_4. The curie points of the materials are lower than that of Fe_3O_4.5. The clinical treatment for brain tumors and tongue tumors were tried for several cases using Fe-Pt alloy implants. The effects of hyperthermia were remarkable, 45.5% for brain tumors and 100% for tongue tumors.

研究了用于肿瘤组织热疗的植入材料，并进行了临床研究。研究结果总结如下：1。Fe-Pt合金热疗植入材料具有居里点低、涡流损耗产热大的特点，其耐腐蚀性能大于不锈钢。然而，当植入兔大腿组织时，x射线分析中检测到少量溶解的铁元素（1.0 × 10^<-4> g/cm^2月）。为了防止合金元素的溶解，采用硅烷和磷酸包覆生物相容性化合物SiO_2。该涂层显著提高了材料的耐蚀性。采用磁滞损失法制备了Fe-Pt合金粉末样品作为发热材料。粉末材料产生的热量足以用于热疗。采用喷雾干燥法对粉末颗粒进行了SiO_2包覆。研究了元素均具有生物相容性的CaO-MgO-Fe_2O_3体系陶瓷材料作为新型热疗粉末植入材料。结果表明，对于（MgO）_<1-x>(Fe_2O_3)_x, x=0.525，对于（CaFe_4O_7）_<1-y>(MgFe_2O_4)_y, y=1.0的材料通过迟滞损失产生的热量较大，比Fe_3O_4大几倍。这些材料的居里点都低于Fe_3O_4.5。应用铁铂合金植入体治疗脑肿瘤和舌部肿瘤的临床试验有几例。热疗的效果显著，脑肿瘤为45.5%，舌部肿瘤为100%。