The Evaluation of Effects of Environmental Cd Exposure on the Relationships of Se, Zn, Cu, Ca, Mg and Cd in Human Tissues

环境镉暴露对人体组织中硒、锌、铜、钙、镁、镉关系影响的评价

• 批准号: 02670230
• 负责人: HONDA Ryumon
• 金额: $ 1.47万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670230/
• 关键词: Environmental Cadmium Exposure; Human Tissues; Serenium; Zinc; Copper; Calcium; Magnesium; 環境カドシウム暴露; 微量元素; 相互影響

Cadmium(Cd), selenium(Se), zinc(Zn), copper(Cu), calcium(Ca)and magnesium(Mg)concentrations were determined in liver, kidney cortex, kidney medulla, pancreas, thyroid, heart, skeletal muscle, aorta and rib, from 51(9 males and 42 females)cadmium-polluted and 75(41 males and 34 females)nonpolluted autopsied subjects. All subjects were over 60 years old.The mean(geometric)Cd concentrations in the tissues of the Cd-polluted group were significantly higher in all tissues except kidney than those in nonpolluted group. The highest ratio of the mean in Cd-polluted group to that in nonpolluted group was found in pancreas with the value of 4.63, followed by thyroid with 4.61. Thus, the tissue in 'which Cd could highly accumulate was considered to be pancreas and thyroid.On the relationship among these elements investigated, Cd correlated strongly with Zn and Cu, especially in liver and kidney. The significant high correlations between Zn and Cu or Mg were found in many tissues.On the other hand, from the data obtained from the correlation matrix of each element in the tissues, Cd showed high correlations among almost all of the tissues. This may be due to the high accumulative ability of Cd in each tissue. Whereas, for Zn, 'Cu and Mg, the high correlation was found between liver, kidney cortex and kidney medulla. These results suggest that Cd metabolism is largely different from the metabolism of Zn, Cu and Mg. Furthermore, in the female nonpolluted subjects, Ca contents in the soft tissues seemed to increase with decreasing in bone Ca due to aging, while in the female Cd-polluted subjects, the similar trend was seen in some cases, but the Ca levels were generally much lower than those in nonpolluted subjects. This suggests that Ca deficiency in their whole body might exist in Cd-polluted women.

本文测定了51例镉污染者和75例非镉污染者尸体中肝、肾皮质、肾髓质、胰腺、甲状腺、心脏、骨骼肌、主动脉和肋骨中镉（Cd）、硒（Se）、锌（Zn）、铜（Cu）、钙（Ca）和镁（Mg）含量。受试者年龄均在60岁以上，除肾脏外，镉污染组各组织中镉的几何平均浓度均显著高于非污染组。镉污染组与未污染组的平均值比值最高的是胰腺，为4.63，其次是甲状腺，为4.61。在所研究的元素之间的关系中，Cd与Zn、Cu的相关性较强，尤其是在肝脏和肾脏中。Zn与Cu、Mg在许多组织中呈极显著的高度相关，而Cd在几乎所有组织中均呈高度相关。这可能是由于镉在各组织中的高积累能力所致。Zn、Cu、Mg在肝、肾皮质和肾髓质之间呈高度相关。这些结果表明，镉的代谢与锌，铜和镁的代谢有很大的不同。此外，在女性非污染受试者中，软组织中的钙含量似乎随着骨钙的减少而增加，由于年龄的增长，而在女性镉污染受试者中，在某些情况下，也看到了类似的趋势，但钙水平普遍低于非污染受试者。提示镉污染妇女可能存在全身钙缺乏。