Prevalence of hands skin abnormalities and latex-specific IgE antibodies in workers using rubber gloves

使用橡胶手套的工人手部皮肤异常和乳胶特异性 IgE 抗体的患病率

• 批准号: 13670392
• 负责人: HONDA Ryumon
• 金额: $ 2.18万
• 依托单位: KANAZAWA MEDICAL UNIVERCITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670392/
• 关键词: latex allergies; rubber gloves; RAST (IgE antibody); contact dermatitis; atopic dermatitis; Shift worker

Natural rubber latex has become an important occupational health concern in recent years, particularly among health care workers, whereas the reports on the other occupational workers who routinely wear latex gloves have been rare. Therefore we examined hands skin abnormalities caused by rubber (latex) gloves among workers in an electronic-parts factory.The total subjects were 965 male and 50 female workers who participated in an annual health check-up. The information about hands skin abnormalities were obtained by a self-recorded questionnaire as well as by a doctor's observation. Latex-specific IgE antibody was assayed by radio allergo sorbent test (RAST) (Pharmacia).RAST was positive in 16 (2.2%) of 736 rubber-gloves-users and 7(3.3%) of 210 non-users, and the difference in the positive rates between the two groups was not statistically significant. The higher levels of the antibody (class 3 and 4), however, were observed by one in each class in the rubber-gloves-users. Recorded subjective symptoms in hands were seen in 184(25.6%) of 718 rubber-gloves-users who answered the questionnaire. In medical histories atopic dermatitis was seen in significantly higher proportion (12.5%) in the 184 subjects with subjective symptoms comparing with 5.2% in 534 subjects with no subjective symptoms (p=0.002). Itching was the most frequent subjective symptom (59.8%) and scale was the next (45.7%). Scale symptom rates tended to be differ in types of job (p=0.070) ; 51.2% in manufacture (rubber gloves are regularly used), 34.8% in technique, 27.3% in others. There was no subjects who had any abnormalities in hands at the time of the health check-up.These results suggests that the almost abnormalities (recorded subjective symptoms) were any other contact dermatitis than latex allergies.

近年来，天然橡胶胶乳已成为一个重要的职业健康问题，特别是在卫生保健工作者中，而其他职业工作者经常戴乳胶手套的报道很少。因此，我们调查了橡胶（乳胶）手套引起的手皮肤异常的工人在一个电子零件厂，总的受试者是965名男性和50名女性工人参加了每年的健康检查。手部皮肤异常的相关信息通过自记问卷和医生观察获得。乳胶特异性IgE抗体测定采用放射性过敏原吸附试验（RAST）（Pharmacia公司），在736名橡胶手套使用者和210名非使用者中，RAST阳性率分别为16人（2.2%）和7人（3.3%），两组间差异无统计学意义。然而，在橡胶手套使用者中，每类中均观察到较高水平的抗体（第3类和第4类）。在回答问卷的718名橡胶手套使用者中，184名（25.6%）出现了手部主观症状。在病史中，184例有主观症状的受试者中特应性皮炎的比例（12.5%）显著高于534例无主观症状的受试者中的5.2%（p=0.002）。瘙痒是最常见的主观症状（59.8%），其次是鳞屑（45.7%）。量表症状发生率在不同工种之间存在差异（p=0.070）; 51.2%在制造业（经常使用橡胶手套），34.8%在技术，27.3%在其他。在健康检查时，没有受试者的手有任何异常。这些结果表明，几乎所有的异常（记录的主观症状）都是乳胶过敏以外的任何其他接触性皮炎。