The changes of antithrombotic function of blood and blood vessel wall with age

血液及血管壁抗血栓功能随年龄的变化

• 批准号: 02670468
• 负责人: SHIRAHATA Akira
• 金额: $ 1.6万
• 依托单位: University of Occupational and Environmental Health Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670468/
• 关键词: Platelet; Blood coagulation; Fiblinolysis; Endothelial cell; Atherosclerosis; Kawasaki disease; Vaculitis; Aging; 血管内皮細胞; トロンボモジュリン; 脂廣; 凝固; 脂屓; 凝固制御因子

In order to clarify the age dependence of antithrombotic function of blood and blood vessel wall, we measured platelet aggregation, natural coagulation inhibitors, fibrinolytic factors and some molecular markers of hemostasis and thrombosis in normal subjects and subjects with present or past history of vasculitis.Results obtained from this research were as follow.1) The plasma levels of molecular markers of platelet, coagulation and fibrinolysis-related proteins were increased in newborn infants, indicating that platelet, coagulation and fibrinolysis systems were activated in neonates. However, no change of these parameters with age was not seen in subjects beyond 1 years old of age.2) The plasma levels of natural coagulation inhibitors were lower in newborn infants than those in adults. However, no age dependence of natural coagulation inhibitors was observed in subjects beyond 1 years old of age.3) The activation of platelet and coagulation system was seen in patients with acute vasculitis. In the patients with kawasaki disease, the activation of those system was observed beyond 1 year after the onset of the disease. On the other hand, fibrinolytic system was depressed in those patients.

为了阐明血液和血管壁的抗肉眼功能的年龄依赖性，我们测量了血小板聚集，自然凝血抑制剂，纤维蛋白溶解因子以及正常受试者的某些分子标记以及血栓形成的某些分子标记以及血栓形成的受试者，具有当前或过去的血管炎的史。新生婴儿中与纤维蛋白溶解相关的蛋白质增加，表明血小板，凝血和纤维蛋白溶解系统在新生儿中被激活。但是，在1岁以上的受试者中没有发现这些参数随着年龄的变化。2）新生婴儿的自然凝血抑制剂的血浆水平低于成年人的血浆水平。然而，在1岁以上的受试者中，没有观察到自然凝血抑制剂的年龄依赖性。3）血小板和凝结系统的激活在急性血管炎的患者中可见。在川崎疾病的患者中，观察到该系统的激活在疾病发作后1年以上。另一方面，这些患者的纤维蛋白水解系统降低。

项目成果

椎木 みどり: "新生児の凝固・線溶阻止因子の動態" 臨床血液. 32. 758-765 (1991)

Midori Shiiki：“新生儿抗凝和纤溶因子的动态”临床血液学 32. 758-765 (1991)。

Shirahata A. et al: "Use of blood products and their recombinant derivatives in the neonatal care" The Japanese Journal of Obstetrical, Gynecological & Neonatal Hematology. 1(3). 3-12 (1991)

Shirahata A. 等人：“血液制品及其重组衍生物在新生儿护理中的应用” 日本妇产科杂志

白播 聡: "遠隔期川崎病罹患児の血液凝固学的検討" 日本小児科学会雑誌. 94. 2608-2613 (1990)

Satoshi Shirahari：“远期川崎病儿童的凝血研究”日本儿科学会杂志 94. 2608-2613 (1990)。

大治 太郎: "健常5歳児のリポ蛋白コレステロールと動脈硬化指数" 小児保健研究. 51. 600-604 (1992)

Taro Oji：“健康 5 岁儿童的脂蛋白胆固醇和动脉硬化指数”儿童健康研究 51. 600-604 (1992)。

白幡 聡: "アレルギー性紫斑病と血液凝固第XIII因子" Biomedical Perspectives. 1. 117-124 (1992)

Satoshi Shirahata：“过敏性紫癜和凝血因子 XIII”《生物医学观点》1. 117-124 (1992)。