The changes of antithrombotic function of blood and blood vessel wall with age

血液及血管壁抗血栓功能随年龄的变化

• 批准号: 02670468
• 负责人: SHIRAHATA Akira
• 金额: $ 1.6万
• 依托单位: University of Occupational and Environmental Health Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670468/
• 关键词: Platelet; Blood coagulation; Fiblinolysis; Endothelial cell; Atherosclerosis; Kawasaki disease; Vaculitis; Aging; 血管内皮細胞; トロンボモジュリン; 脂廣; 凝固; 脂屓; 凝固制御因子

In order to clarify the age dependence of antithrombotic function of blood and blood vessel wall, we measured platelet aggregation, natural coagulation inhibitors, fibrinolytic factors and some molecular markers of hemostasis and thrombosis in normal subjects and subjects with present or past history of vasculitis.Results obtained from this research were as follow.1) The plasma levels of molecular markers of platelet, coagulation and fibrinolysis-related proteins were increased in newborn infants, indicating that platelet, coagulation and fibrinolysis systems were activated in neonates. However, no change of these parameters with age was not seen in subjects beyond 1 years old of age.2) The plasma levels of natural coagulation inhibitors were lower in newborn infants than those in adults. However, no age dependence of natural coagulation inhibitors was observed in subjects beyond 1 years old of age.3) The activation of platelet and coagulation system was seen in patients with acute vasculitis. In the patients with kawasaki disease, the activation of those system was observed beyond 1 year after the onset of the disease. On the other hand, fibrinolytic system was depressed in those patients.

为探讨血液和血管壁抗血栓功能的年龄依赖性，我们测定了正常人和有血管炎病史者的血小板聚集、自然凝血抑制因子、纤溶因子及部分止血和血栓形成的分子标志物，结果表明：1）血小板分子标志物、新生儿凝血和纤溶相关蛋白升高，提示新生儿血小板、凝血和纤溶系统处于激活状态。然而，在1岁以上的受试者中未观察到这些参数随年龄的变化。2）新生儿血浆天然凝血抑制物水平低于成人。3）急性血管炎患者存在血小板和凝血系统的激活。在川崎患者中，这些系统的激活在发病后1年以上观察到。另一方面，这些患者的纤溶系统受到抑制。

项目成果

椎木 みどり: "新生児の凝固・線溶阻止因子の動態" 臨床血液. 32. 758-765 (1991)

Midori Shiiki：“新生儿抗凝和纤溶因子的动态”临床血液学 32. 758-765 (1991)。

Shirahata A. et al: "Use of blood products and their recombinant derivatives in the neonatal care" The Japanese Journal of Obstetrical, Gynecological & Neonatal Hematology. 1(3). 3-12 (1991)

Shirahata A. 等人：“血液制品及其重组衍生物在新生儿护理中的应用” 日本妇产科杂志

白幡 聡: "アレルギー性紫斑病と血液凝固第XIII因子" Biomedical Perspectives. 1. 117-124 (1992)

Satoshi Shirahata：“过敏性紫癜和凝血因子 XIII”《生物医学观点》1. 117-124 (1992)。

大治 太郎: "健常5歳児のリポ蛋白コレステロールと動脈硬化指数" 小児保健研究. 51. 600-604 (1992)

Taro Oji：“健康 5 岁儿童的脂蛋白胆固醇和动脉硬化指数”儿童健康研究 51. 600-604 (1992)。

白播 聡: "遠隔期川崎病罹患児の血液凝固学的検討" 日本小児科学会雑誌. 94. 2608-2613 (1990)

Satoshi Shirahari：“远期川崎病儿童的凝血研究”日本儿科学会杂志 94. 2608-2613 (1990)。