Studies on the molecular markers of coagulation, fibrinolysis and vascular endothelial cells in children

我们检测了单纯性肥胖、糖尿病或川崎病儿童的凝血、纤溶和血管内皮细胞的分子标志物，以阐明这些儿童动脉粥样硬化进展的预后危险因素。本研究项目获得的主要数据如下：(1)中度或重度肥胖儿童血浆纤溶酶原激活物抑制剂1 （PAI-1）水平明显高于同龄对照组。另一方面，重度肥胖儿童血浆组织纤溶酶原激活物（TPA）水平明显低于中度肥胖儿童。(2)有川崎病病史的患儿血浆PAI-1水平明显高于同龄对照组，且有持续或短暂冠状动脉病变史的川崎病患儿血浆PAI-1水平明显高于无这些并发症的川崎病患儿。这些结果表明，纤维蛋白溶解系统的抑制可能与生活方式相关疾病儿童动脉粥样硬化的进展有关。

We examined the molecular markers of coagulation, fibrinolysis and vascular endothelial cells in children with simple obesity, diabetes mellitus or Kawasaki disease in order to clarify the prognostic risk factors for the progression of atherosclerosis in these children. Main data obtained from this research project were as follows.(1) Plasma levels of plasminogen activator inhibitor 1 ( PAI-1 ) were significantly higher in children with moderate or severe obesity than in age-matched control. On the other hand, plasma levels of tissue plasminogen activator ( TPA ) were significantly lower in children with severe obesity than in those with moderate obesity.(2) In children with past histories of Kawasaki disease, plasma PAI-1 levels were significantly higher compared with age-matched control Furthermore, these levels were significantly higher in children suffered from Kawasaki disease with histories of persistent or transient coronary artery lesions than in children suffered from Kawasaki disease without those complications.Those results indicate that suppression of fibrinolytic system may be responsible for the progression of atherosclerosis in children with life style-related disease.