尿路悪性腫瘍の浸潤、転移において細胞外基質の果たす役割について

近年来，研究发现，多种细胞外基质在恶性肿瘤的侵袭和转移过程中发挥着重要作用。在先前的研究中，我们报道了肾细胞癌和前列腺癌的血清层粘连蛋白浓度升高，并且在转移患者中显著升高。然而，在膀胱癌中，该水平仅在转移的那些中升高，表明层粘连蛋白的血清浓度可用作恶性肿瘤中转移或临床进展的标志物。在本研究中，我们测量了构成基底膜的IV型胶原7S-结构域和层粘连蛋白的血清浓度，并将结果与层粘连蛋白的血清浓度进行比较，尽管肾细胞癌、前列腺癌和膀胱癌转移患者血清层粘连蛋白浓度升高，但在任何肿瘤类型中IV型胶原7S-结构域的血清浓度均未显著升高。在任何转移组中，IV型胶原7S-结构域的血清浓度均无显著差异。

In recent years, it has become clear that various extracellular substrates play an important role in the process of invasion and metastasis of malignant tumors. In a previous study, we reported that the serum concentration of laminin in renal cell carcinoma and prostate cancer is elevated, and furthermore, is remarkably high in patients with metastasis. However, in bladder cancer, this level is elevated only in those with metastasis, indicating that the serum concentration of laminin is useful as a marker of metastasis or of clinical progression in the malignant tumor.In the present study, we measured the serum concentration of type IV collagen 7S-domain, which constructs the basement membrane as well as laminin, and compared the result with the serum concentration of laminin, to evaluate the clinical significance of the findings.The serum concentration of type IV collagen 7S-domain was not elevated significantly in any tumor type, although the serum concentration of laminin was elevated in patients with renal cell carcinoma, prostate cancer and bladder cancer with metastasis. There were no significant differences in the serum concentration of type IV collagen 7S-domain in any group with metastasis.