Antiplaque Activity of Fluoride Releasing Resin

释氟树脂的抗牙菌斑活性

基本信息

  • 批准号:
    02670852
  • 负责人:
  • 金额:
    $ 1.34万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1990
  • 资助国家:
    日本
  • 起止时间:
    1990 至 1991
  • 项目状态:
    已结题

项目摘要

It has been recognized that a profittable release of fluoride ion from dental materials increased the fluoride content of tooth structure and decreased solubility of enamel and dentin. It also has been reported that plaque accumulation is inhibited on the surface of fluoride releasing dental materials. However, fluoride has been successfully incorporated into few dental restorative materials. Recently a fluoride releasing resin has thus been developed and is anticipated to be used for preventing dental caries. This resin releases fluoride constantly without the concomitant reduction in physical properties. In this research we thus studied the antiplaque ability of this resin by examining the effect of this resin on Streptococcus sobrinus and its synthesized glucosyltransferase. The eluate from this resin showed antibacterial activity and inhibited the production of glucan. However, the amount of released fluoride was not enough to exert the antienzymatic and antibacterial activity. In addition, quntitative measurement of the resin component such as resin monomer by high perforamance liquid chromatography showed that some eluted monomers significantly inhibited glucosyltransferase. The organism and glucan synthesized in situ by this bacterium, minimally adhered to the surface of fluoride releasing resin because this resin had the small critical surface tension of the solid, at which complete wetting occurs, compared to the control resin not having fluoride releasing mechanism(MF-MMA copolymer). Thus this resin discorages on adhesion of oral streptococci to it.From these results it was concluded that fluoride releasing resin will prevent dental caries by showing antilpaque activity. From a point of view of clinical application, studies will be in progress in which the fluoridation of whole human tooth structure by this resin is investigated.
人们已经认识到,从牙科材料中有益地释放氟离子增加了牙齿结构中的氟化物含量,降低了牙釉质和牙本质的溶解度。也有报道说,牙菌斑在释放氟化物的牙科材料表面的积累受到抑制。然而,氟化物已成功地纳入少数牙齿修复材料。最近开发了一种氟释放树脂,有望用于预防龋齿。这种树脂不断地释放氟化物,而不会同时降低其物理性能。本研究通过观察该树脂对sobrinus链球菌及其合成的葡萄糖基转移酶的作用来研究该树脂的抗斑块能力。该树脂的洗脱液具有抑菌活性,抑制葡聚糖的产生。然而,释放的氟化物量不足以发挥其抗酶和抗菌活性。此外,通过高效液相色谱法对树脂单体等树脂组分的定量测定表明,洗脱后的部分单体对葡萄糖基转移酶有明显的抑制作用。与不具有氟释放机制的对照树脂(MF-MMA共聚物)相比,该细菌原位合成的生物体和葡聚糖在氟释放树脂表面的粘附程度最低,因为该树脂具有较小的固体临界表面张力,在该临界表面张力下发生完全润湿。因此,这种树脂阻止了口腔链球菌对它的粘附。综上所述,氟释放树脂具有防龋作用。从临床应用的角度来看,研究该树脂对人类全牙结构的氟化作用将继续进行。

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
河合 啓次: "フッ素徐放性レジンによる菌体外グルカン合成酵素の抑制に関する研究" 日本歯科保存学雑誌. 32. 1404-1411 (1989)
Keiji Kawai:“氟化物缓释树脂抑制细胞外葡聚糖合酶的研究”日本保守牙科杂志 32. 1404-1411 (1989)。
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    0
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河合 啓次: "フッ素徐放性レジンのプラ-ク付着性に関する研究" 日本歯科保存学雑誌. 33. 1353-1360 (1990)
Keiji Kawai:“缓释氟树脂牙菌斑粘附的研究”日本保守牙科杂志 33. 1353-1360 (1990)。
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    0
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河合 啓次: "フッ素徐放性レジンの抗菌性" 日本歯科保存学雑誌. 33. 1609-1616 (1990)
Keiji Kawai:“氟化物缓释树脂的抗菌性能”日本保守牙科杂志 33. 1609-1616 (1990)。
  • DOI:
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    0
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KENJI KAWAI: "Factors Affecting the Amount of Fluoride Ion Release from Fluoride Releasing Resin" J. Osaka Univ. Dent. School.30. 78-85 (1990)
KENJI KAWAI:“影响氟化物释放树脂中氟化物离子释放量的因素” J. Osaka Univ.
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  • 影响因子:
    0
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KEIJI KAWAI: "Inhibition of Extracellular Glucosyltransferase by Eluate from Fluoride-releasing Resin" Japan. J. Conserv. Dent.32. 1404-1411 (1989)
KEIJI KAWAI:“释氟树脂洗脱液对细胞外葡萄糖基转移酶的抑制”,日本。
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    0
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TSUCHITANI Yasuhiko其他文献

TSUCHITANI Yasuhiko的其他文献

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{{ truncateString('TSUCHITANI Yasuhiko', 18)}}的其他基金

Fatigue Crack Propagation in Composite Resins
复合树脂中的疲劳裂纹扩展
  • 批准号:
    04454469
  • 财政年份:
    1992
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
A study on reduction in the rate of progress and prevention of the root caries by fluoride-releasing polymers
含氟聚合物减缓和预防根部龋齿进展的研究
  • 批准号:
    61480397
  • 财政年份:
    1986
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
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