A study on reduction in the rate of progress and prevention of the root caries by fluoride-releasing polymers

含氟聚合物减缓和预防根部龋齿进展的研究

• 批准号: 61480397
• 负责人: TSUCHITANI Yasuhiko
• 金额: $ 3.01万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480397/
• 关键词: Prevention of root caries; fluoride-releasing polymer; fluoride uptake; acid resistance; 耐摩耗性; フッ素イオン徐放性; シーラント; 根面う蝕進行抑制; 人工う蝕; シーラント浸透層

Periodontal disease and aging often expose the relatively caries-prone root dentin. This study investigates the effect of light-cured fluoride-releasing sealant (F-sealant) containing methacryloyl fluoride (MF) - methyl mathacrylate (MMA) copolymer on the anti-caries properties of the root dentin; e.g., acid resistance and abrasion resistance.F-sealant and abrasion resistance greater than that of root dentin. Following application of F-sealant, the root dentin acquired a scanning electron microscopically demonstrable sealant penetration layer of about 3 <micrn>m in thickness. The rate of fluoride release from F-sealant into a phosphate buffer (pH 7, 37゜C) was about 12-30 <micrn>g/day during the first 24 hr, rapidly decreased by the 100th day and thereafter maintained a constant value of about 1-2 <micrn>g/day until the 300th day. At the end of experiment (the 540th day), the F-sealant still continued releasing a small amount of fluoride (0.5-1 <micrn>g/day). The greater the molar fraction of MF, the greater the rate of fluoride release was. Immediately after the F-sealant application, fluoride was detected at the depth of 10 <micrn>m from the dentin surface. During the incubation of preparations in a phosphate buffer (pH 7, 37゜C), fluoride gradually infiltrated the dentin and reached 100 <micrn>m at the 90th day. The acid resistance of the dentin after removal of F-sealant was significantly greater than that after removal of C-sealant (without MF-MMA copolymer). This acid resistance gradually increased for up to 90 days after application of F-sealant.The above results suggest that the F-sealant enhances the acid resistance of the dentin through a long term transmittal from the F-sealant to the dentin of fluoride. This enhancement of acid resistance of the dentin, together with a possible contact inhibition of the dentin from the oral environment, is considered to contribute to reduction of the rate of progress of and/or prevention of the root caries.

牙周病和衰老往往暴露出相对容易龋齿的根部牙本质。研究了含甲基丙烯酰氟(MF)-甲基丙烯酸甲酯(MMA)共聚物的光固化释氟封闭剂(F封闭剂)对根面牙本质防龋性的影响，如耐酸性、耐磨性等。使用F封闭剂后，根部牙本质获得了扫描电子显微镜下可见的封闭剂渗透层，厚度约为3微米。氟化物从F密封胶释放到磷酸盐缓冲液(pH 7，37゜C)中的速率在最初24小时内约为12-30微克/天，到第100天迅速下降，此后一直保持在约1-2微克/天的恒定值，直到第300天。实验结束时(第540天)，F封闭剂仍有少量氟化物释放(0.5-1微克/天)。微球的摩尔分数越大，氟化物的释放速率越大。在使用氟封闭剂后，立即在牙本质表面10微米以下的深度检测到氟化物。在磷酸盐缓冲液(pH 7，37゜C)中孵育过程中，氟化物逐渐渗入牙本质，在第90天达到100微米。去除F封闭剂后牙本质的耐酸性明显高于去除C封闭剂(不含MF-MMA共聚物)后牙本质的耐酸性。使用F封闭剂后90天，这种耐酸性逐渐增强。以上结果表明，F封闭剂通过长期从F封闭剂传递到牙本质中的氟化物来增强牙本质的耐酸性。这种牙本质抗酸能力的增强，再加上口腔环境对牙本质接触的可能抑制，被认为有助于降低根面龋病的进展速度和/或预防根面龋病。