权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Basic study for establishment of usefulness of a new inbred rat strain THA in brain science

建立新近交系大鼠THA品系在脑科学中的实用性的基础研究

基本信息

批准号：
02680041
负责人：
SHIGETA Sadayoshi
金额：
$ 0.9万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

1.Neurobehavioral characteristics of the THA rat strain The THA rat strain performed superior learning and displayed small individual differences of learning performance, not only in the Sidman avoidance task, but also in two different tasks, namely, water E-maze and two-way shuttle avoidance, compared to the Jcl-Wistar strain. No apparent difference was present in developement, circadian rhysm of spontaneous activity, and open-field activity between the two strains.2.Neurochemical characteristics of the THA rat strain The THA rat strain released much Ach compared to the Jcl-Wistar strain in striatum, but no significant difference was present in cortex between the two strain s. The THA rat strain showed high responce of Ach release to scopolamin, compared to the Jcl-Wistar strain in cortex, but no apparent difference was indicated in striatum between the two strains. No difference was present in release of mono-amine metabolites between the two strains.3.Genetic characteristics of the THA rat strain The amylase-1 on the loci of the THA rat strain was different to that of the Jcl-Wistar strain.4.Immunological characteristics of the THA rat strain The THA rat strain showed much T-cell subset, especially Th cell, compared to the Jcl-Wistar strain in the examination of subpopulation of lymphocyte. No difference were indicated in the proliferative response, and mixed lymphocyte reaction between the two strains.

1. THA大鼠品系的神经行为特征与Jcl-Wistar品系相比，THA大鼠品系进行上级学习，并且不仅在Sidman回避任务中，而且在两个不同的任务，即水E-迷宫和双向穿梭回避中，显示出学习表现的小的个体差异。两品系大鼠在发育、自发活动的昼夜节律、旷场活动等方面无明显差异。2. THA大鼠品系的神经化学特征THA大鼠品系与Jcl-Wistar品系相比，在纹状体释放更多的Ach，而在皮层释放的Ach在两品系之间无明显差异。THA品系大鼠皮层Ach释放对东莨菪碱的反应性高于Jcl-Wistar品系，而纹状体Ach释放对东莨菪碱的反应性两品系大鼠无明显差异。3. THA大鼠品系的遗传学特征THA大鼠品系与Jcl-Wistar大鼠品系的淀粉酶-1位点存在差异。4. THA大鼠品系的免疫学特征THA大鼠品系淋巴细胞亚群的检测结果显示，与Jcl-Wistar大鼠品系相比，THA大鼠品系的T细胞亚群，尤其是Th细胞明显增多。增殖反应和混合淋巴细胞反应两株间无差异。