Longitudinales Monitoring der Netzhautfunktion bei altersabhängigen Veränderungen der Makula unter Berücksichtigung des Spontanverlaufes und von therapeutischen Eingriffen (Multifocal electroretinography in age-related macular degeneration: Monitoring of

纵向监测黄斑中年龄相关变化的视网膜功能，考虑自发进展和治疗干预（年龄相关性黄斑变性的多焦视网膜电图：监测

• 批准号: 5244106
• 负责人: Privatdozent Dr. Bernhard Jurklies
• 金额: --
• 依托单位: Klinik für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2000
• 资助国家: 德国
• 起止时间: 1999-12-31 至 2002-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5244106?language=en
• 关键词: Longitudinales; Monitoring; der; Netzhautfunktion; bei

Multifocal ERG (MfERG) allows an objective assessment and topographical mapping of retinal function over the central visual field. Findings of the normal control group were extended particularly for the subjects of 50 years to differentiate ageing changes from those due to AMD. The AMD subgroups were increased in sample size. They revealed statistically significant differences from the control group and in part from each other. Based on our first results the sample size of the patients will be increased further particularly for those groups with a small sample size. Fixation will be monitored using a fundus camera to exclude effects on retinal responses particularly when visual acuity is significantly reduced. To study the long-term effects on retinal function longitudinal follow-up examinations will be continued and extended for different subgroups of AMD. They should help to identify prognostic factors and risk factors for a limited outcome. The recordings will be performed longitudinally prior to and after therapeutic intervention (photodynamic therapy [PDT], macular surgery) to determine the effects of therapeutic modalities on local retinal function. Our results suggest a decrease in response densities after several PDT-treatments. Extension of the follow-up may help to evaluate possible treatment-related side effects on retinal function. Therapeutic modalities are limited in particular due to the loss of photoreceptors. Further, an increase in follow up and sample size of the untreated group may help to differentiate AMD-related effects from treatment related effects. A longitudinal study of retinal function by MfERG may help to determine the point of irreversible damage of photoreceptor function making successful therapeutic intervention difficult. Therefore, to determine changes in retinal function by MfERG will help to explain success or failure in patients undergoing therapy.

多焦ERG（MfERG）允许在中央视野上对视网膜功能进行客观评估和地形图绘制。正常对照组的研究结果进行了扩展，特别是50岁的受试者，以区分老化变化，由于AMD。AMD亚组的样本量增加。他们显示出与对照组的统计学显着差异，部分来自彼此。根据我们的第一个结果，患者的样本量将进一步增加，特别是对于那些样本量较小的组。将使用眼底照相机监测注视，以排除对视网膜反应的影响，特别是当视力显著降低时。为了研究对视网膜功能的长期影响，将继续对不同亚组的AMD进行纵向随访检查。他们应该有助于确定预后因素和风险因素的有限结果。将在治疗干预（光动力疗法[PDT]、黄斑手术）前后纵向进行记录，以确定治疗方式对局部视网膜功能的影响。我们的研究结果表明，在几个PDT治疗后的反应密度下降。延长随访时间可能有助于评估治疗对视网膜功能可能产生的副作用。特别是由于光感受器的损失，治疗方式受到限制。此外，未治疗组的随访和样本量的增加可能有助于区分AMD相关效应和治疗相关效应。通过MfERG进行的视网膜功能的纵向研究可能有助于确定使成功的治疗干预变得困难的光感受器功能的不可逆损伤的点。因此，通过MfERG确定视网膜功能的变化将有助于解释接受治疗的患者的成功或失败。