Longitudinales Monitoring der Netzhautfunktion bei altersabhängigen Veränderungen der Makula unter Berücksichtigung des Spontanverlaufes und von therapeutischen Eingriffen (Multifocal electroretinography in age-related macular degeneration: Monitoring of

多焦ERG(MfERG)可以在中心视野上对视网膜功能进行客观评估和地形图绘制。正常对照组的发现被扩大，特别是对于50岁的受试者，以区分年龄变化和AMD所致的变化。AMD亚组的样本量增加。他们显示出与对照组的统计上的显著差异，而且彼此之间也存在部分差异。根据我们的第一个结果，患者的样本量将进一步增加，特别是对于那些样本量较小的群体。将使用眼底相机监测注视情况，以排除对视网膜反应的影响，特别是当视力明显下降时。为了研究对视网膜功能的长期影响，将对AMD的不同亚组继续和延长纵向随访检查。它们应该有助于确定预后因素和有限结果的风险因素。这些记录将在治疗干预(光动力疗法[PDT]、黄斑手术)之前和之后进行纵向记录，以确定治疗方式对局部视网膜功能的影响。我们的结果表明，经过几次PDT治疗后，反应密度降低了。延长随访时间可能有助于评估治疗对视网膜功能可能产生的副作用。治疗方式受到限制，特别是由于光感受器的丧失。此外，增加未治疗组的随访和样本量可能有助于区分AMD相关效应和治疗相关效应。MfERG对视网膜功能的纵向研究可能有助于确定光感受器功能的不可逆损害点，使成功的治疗干预变得困难。因此，通过MfERG确定视网膜功能的变化将有助于解释接受治疗的患者的成功或失败。

Multifocal ERG (MfERG) allows an objective assessment and topographical mapping of retinal function over the central visual field. Findings of the normal control group were extended particularly for the subjects of 50 years to differentiate ageing changes from those due to AMD. The AMD subgroups were increased in sample size. They revealed statistically significant differences from the control group and in part from each other. Based on our first results the sample size of the patients will be increased further particularly for those groups with a small sample size. Fixation will be monitored using a fundus camera to exclude effects on retinal responses particularly when visual acuity is significantly reduced. To study the long-term effects on retinal function longitudinal follow-up examinations will be continued and extended for different subgroups of AMD. They should help to identify prognostic factors and risk factors for a limited outcome. The recordings will be performed longitudinally prior to and after therapeutic intervention (photodynamic therapy [PDT], macular surgery) to determine the effects of therapeutic modalities on local retinal function. Our results suggest a decrease in response densities after several PDT-treatments. Extension of the follow-up may help to evaluate possible treatment-related side effects on retinal function. Therapeutic modalities are limited in particular due to the loss of photoreceptors. Further, an increase in follow up and sample size of the untreated group may help to differentiate AMD-related effects from treatment related effects. A longitudinal study of retinal function by MfERG may help to determine the point of irreversible damage of photoreceptor function making successful therapeutic intervention difficult. Therefore, to determine changes in retinal function by MfERG will help to explain success or failure in patients undergoing therapy.