ORGANIC CHEMISTRY OF THE BIOSYSTEM CONTROL SUBSTANCES

1.神经毒素的结构测定、合成及传递机制：以不同底物白羽为底物，研究谷氨酸受体上作用点的空间排列。用合成模型(Hirama)研究了雪茄毒素的绝对构型。从黄蜂中分离出两种神经毒素(Okumura)，推测其结构。对孢子虫毒素和冈田酸的中毒机理进行了研究。采用新方法(Isobe)合成了河豚毒素的重要中间体。确定了从植物中分离的神经营养化合物的结构(KoDama)。细胞生长调控因子：用新开发的方法(Murai)合成了(+)-月桂花素和(-)-十二烷基炔。植物的抗侵染活性与细胞中存在的不饱和脂肪酸(T.Kato)的烯丙基过氧化密切相关。合成了万古霉素的活性部分，并对其杂交菌株(山村)的产物进行了结构鉴定。模拟…合成了更多具有与紫杉醇苷相当的DNA切割活性的蕨类致癌物质，从紫杉醇糖苷中分离得到抗肿瘤化合物，并从海洋动物(Yamada)中分离得到抗肿瘤化合物。从水龙骨科植物中分离得到8个抗肿瘤活性启动子，并对其结构进行了鉴定(Hayashi)。对各种海洋生物活性化合物(苦参素)进行了绝对构型测定和构型分析。合成了具有细胞毒性的对苯二乙酸酯(Isoe)。从毛冬青属植物中分离得到具有细胞毒性的孜然类化合物。解热、化感和免疫佐剂活性：测定了比目鱼(Tchibana)防御肽的结构。从革兰氏阴性菌合成了免疫佐剂脂磷壁酸(Kusumoto)。进行了景天二萜类化合物的合成研究(Tokoryama)。以诺皮酮(M，Kato)为原料，进行了菊黄素和环伪苦参素A的合成研究。实现了抗酶试剂Didside Palaunic的全合成和绝对构型(UDA)。从蕨类植物(Suga)中分离得到化感作用和离子转运促进剂的化合物。从紫苏(Nakayama)叶中分离到抗酶活性物质。从海洋植物中分离得到5个对海囊受精卵细胞设计具有抑制活性的二萜类化合物，并对其结构进行了鉴定。较少

1.Structural determination,synthesis and transmission mechanism of neurotoxin: Spatial arrangement of action points in glutamate receptor was studied using various substrates(Shirahama). Absolute configuration of cigatoxin was studied using synthesized models(Hirama). Structures of two neurotoxins isolated from wasps were deduced(Okumura). Mechanism of poisoning for palytoxin and okadaic acid was studied(Uemua). An important intermediate for synthesis of tetrodotoxin was synthesized via new method (Isobe). The structures of neurotrophic compounds isolated from plants were determined(Kodama).2. Control factor for cell growth: (+)-Laurencin and (-)-dactylyne were totally synthesized by newly developed method(Murai). Antiinfection activity of plants is found to be closely related with allylperoxidation of unsaturated fatty acids existing in the cells(T.Kato). The active part of vancomycin was synthesized and the structures of products from hybrid strains were determined(Yamamura). Analogs … More of bracken carcinogen,whose DNA cleaving activities were equivalents to ptaxiloside were synthesized and antitumoric compound was isolated from ptaxiloside, were synthesized and antitumoric compounds was isolated from marine animals (Yamada). Eight antitumoric activity promotors were isolated from Polypolaceae and their structures were determined(Hayashi). The determination of absolute configuration and configurational analysis were performed about various marine bioactive compounds(Kusumi). Cytotoxic ent-udoteatrial diacetate was synthesized (Isoe). Cytotoxic cumarines were isolated from Toddalis species(Mori).3. Antifeadant,allelopasy and immnoadjuvant activities: The structures of defensive peptides of flatfishes were determined(Tachibana). Immnoadjuvant lipoteichoic acid from gram-negative bacteria was synthesized (Kusumoto). Synthetic studies on clerodane diterpenoids were performed(Tokoroyama). Synthetic studies on jubavion and secopseudopeterocin A were carried out employing nopinone as a starting material(M,Kato). Total synthesis and absolute configuration of dysideapalaunic acid,antienzymatic agent, were achieved(Uda). The compounds showing allelopasy and promotors of iontransport were isolated from ferns(Suga). Antienzymatics were isolated from leaves of perilla(Nakayama). Five diterpenes, which show inhibitory activity on the cell devisoin of fertilized ascidian eggs, were isolated from marine plants and their structures were determined(Ochi). Less