Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA

对单核金属络合物与DNA相互作用的研究极大地加深了我们对小分子识别DNA上特定位置的方式的理解。然而，为了设计针对特定基因的药物，从而有可能控制基因的表达，有必要研究可以与更大的DNA片段相关联的金属络合物的结合。利用申请者的综合专业知识，建议以立体专一性合成双核配合物并研究它们的DNA结合。这将极大地帮助开发可以选择性地针对基因和改变的DNA的药物。

Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.