飼料のアデニンとその代謝物はニワトリヒナで腎腫大を引き起こすか

饲喂腺嘌呤及其代谢物会导致雏鸡肾脏肿大吗？

• 批准号: 03660292
• 负责人: 唐澤 豊
• 金额: $ 1.02万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03660292/
• 关键词: 飼料アデニン; 飼料RNA; ニワトリ; 腎腫大

単細胞蛋白質中に多量に含まれるRNAの構成アデニンが,単細胞蛋白質給与時にみられる成長遅滞,腎腫大および飼料摂取量の低下の原因物質であるかどうか,またその機構はどのようになっているかどうかを検討した。まずRNAの消化の結果遊離アデニンが生成されアデニンの形で吸収されるかどうかを単離腸粘膜細胞を使った実験とin situ吸収実験によって検討した。その結果,消化管内で遊離のアデニンは代謝されにくくそのまま吸収されるが,消化管内でヌクレオチドやヌクレオシドから遊離のアデニンが生成されることはなく,RNA給与時にはAMPやアデノシンからアデニンの形を経て体内に取り込まれる可能性はないことが明らかにハった。この結果は,RNA給与時とアデニン給与時にみられる一見同じような腎腫大が異なる原因物質とメカニズムで起っていることを示唆している。次にRNA給与とアデニン給与によって起る害作用を詳細に検討した。その結果次の3点が明らかになった。(1)RNA給与とアデニン給与によって起る成長遅滞,飼料摂取量の低下および腎の腫大は外見上両区で同じである。(2)RNA給与時には腎中にリンとカルシウムの蓄積がみられたが,アデニン給与時般はこれらを検出できなかった。(3)RNA給与時には腎に2,3ーDHAが存在しなかったが,アデニン給与時には腎中にこれを検出した。したがってRNA給与時にみられる腎腫大はRNA中のリンによって起こり,RNA中のヌクレオチドアデニンによっては腎腫大が起らないことが明らかになった。本研究の結果に基づいて,RNA中のリン含量に相当するリンの給与実験を行い,腎へのリンの蓄積の確認と軽減法を検討することを計画している。

There is a large amount of malondialdehyde (RNA) in the cell protein chain, which causes the growth and growth of the cell protein. When the concentration of the protein in the cell is high, the amount of the protein in the cell is low. The reason for the increase in the amount of the protein is that the reason is very low, and the temperature is very high. The results of the RNA digestion test showed that the in situ was isolated from the mucous membrane so that it could be isolated from the mucous membrane. According to the results, the digestive tract was isolated from the digestive tract and the digestive tract was isolated from the digestive tract. the results showed that the digestive tract was isolated from the digestive tract. the results showed that the digestive tract was isolated from the digestive tract. the results showed that the digestive tract was isolated from the digestive tract and the digestive tract was isolated from the digestive tract. in the results, the digestive tract was isolated from the digestive tract, and RNA was used to detect the possibility that the AMP could be detected in the body. As a result of the results, RNA gave the same information to the same customer as to the cause of the accident in the same time. The second RNA will have a harmful effect on the customer and the customer. The second time is three o'clock and the next time is three o'clock. (1) the amount of RNA is higher than that of the control, and the growth is slow, and the amount of material is low. (2) RNA is responsible for the storage of information in the market, and the distribution of information is available at the same time. (3) RNA is responsible for the distribution of information in the DHA system. Please contact the RNA for the information in the RNA, while in the RNA, you will need to know if you want to know the truth. The results of this study show that the content of trace elements in RNA is very sensitive to that of the bank, and that it is necessary to make sure that the method is accurate.

项目成果

Y.Karasawa: "Absorption and metabolism of purines by the lower intestine of the chicken." Comparative Biochemistry and Physiology. 100A. 227-230 (1991)

Y.Karasawa：“鸡的下肠对嘌呤的吸收和代谢。”

Y.Karasawa: "Absorption and metabolism of purines by the small intestine of the chicken." Comparative Biochemistry and Physiology. 99A. 235-240 (1991)

Y.Karasawa：“鸡的小肠对嘌呤的吸收和代谢。”