Molecular genetic analysis of muirne senile amyloidosis.

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From the two-year investigation entitled "Molecular genetic analysis of mouse senile amyloidosis", we found the followings,1. The presence of a genetic element other than molecular type of amyloid precursor protein apoA-II which modifies the development of mouse senile amyloidosis was deduced from the genetic analysis using F1, F2, and back-crossed mice between the A/J and SAM-P/1 strains of mice.2. The progress of senescence may accelerate the development of mouse senile amyloidosis.3. A genome mapping system using endogenous leukemia proviruses as a DNA marker has been developed for genetic analysis and positional cloning of genetic elements modifying amyloidosis.4. Congenic strains of mice carrying amyloidogenic apoA-II (Apoa2^c) on the genetic background of SAM-R/1 with normal aging process and amyloid-resistant apoA-II (Apoa2^b) on the genetic background of SAM-P/1 with accelerated aging process were developed.5. Using congenic strains of mice, it was revealed that (1), Apoa2^c reduced the concentration and particle size of serum high density lipoprotein, (2) Apoa2^c accelerates the development of mouse senile amyloidosis.