Comprehensive Proteome Analysis of Age-related Changes in Amyloid Like Aggregates

点击翻译按钮获取中文摘要

Comprehensive and quantitative proteome analysis using LS/MS/MS system was performed to amyloid fibrils /amyloid like aggregates protein fractions which were isolated form 1) the brain, liver, heart and muscle of young and old mice, and 2) the livers of mice induced amyloidosis with the injection of amyloid fibrils.1) Over 40 proteins which were increased significantly in the old mouse brain were identified in amyloid fibrils/amyloid like aggregates fractions.2) Apolipoprotein E, clusterin, vetronectin and polyubiquitin were increased in amyloid fractions associated with AApoAII amyloid deposition in the lever.