Development of a new method for studying spinal reflex activities on single motoneurones in man.
开发一种研究人类单个运动神经元脊髓反射活动的新方法。
基本信息
- 批准号:03670417
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1.A new method for studying spinal reflex activities on single motoneurones was developed by recording single motor units. (1) The computer program was developed for this project. (2) A unitary H-reflex was evoked by stimulating the homonymous nerve. (3) The stimulus intensity was automatically adjusted with a computer so that the firing probability of a motor unit discharge converged to 50% : the intensity was intensified when the motor unit had been fired by a previous stimulus and it was weakened when not fired. The threshold intensity for the Ia fibers in the nerve was determined with the post-stimulus-time-histogram(PSTH)method, and it was subtracted from the intensity with the probability of 50%. The resulting intensity was termed 'critical firihg stimulus (CFS)', which indicated the excitability of the correspondent motoneurone. (4) Effects of peripheral inputs on a single motoneurone was assessed by change in CFS when conditioning stimuli were applied to a certain nerve in prio … More r to the test stimuli. (5) The thresholds of motor units was determined as the critical firing level(CFL), which was the size of compound H-reflexes with the firing probability of the motor unit to be 50%.2. The results obtained by the CFS method were compared with those by the conventional H-reflex method. (1) The pathways examined were reciprocal Ia inhibition and heteronymous Ia facilitation. (2) The data with the two methods were highly correlated. (3) The sensitivities of the two methods were almost the same. (4) The existence and extent of the reflex activities depended on the motor units.3. The heteronymous Ia facilitation from the quadriceps to soleus muscle was observed in 51.3% of the motor units examined, which was somewhat lower in frequency than in the cat and monkey.4. Change in reciprocal Ia inhibition from the common peroneal nerve to the soleus muscle during tonic pretibial contraction had been controversial owing to the difficulties in difflerentiating the effects on individual motoneurones from those on the motoneuronal pool. The CFS method, which revealed effects on individual motoneurones specifically, demonstrated increase in the inhibition.5. The CFS method promises more accurate evaluation of reflex activities on individual motoneu-rones, and is superior to the PSTH method in that examination is possible not only during voluntary contraction of the examined muscle but also in the resting state and even during antagonist contraction. Less
1.建立了一种通过记录单个运动单位来研究单个运动神经元脊髓反射活动的新方法。(1)计算机程序是为这个项目开发的。(2)刺激同侧神经可诱发单一的H反射。(3)用计算机自动调节刺激强度,使得运动单位放电的放电概率收敛到50%:当运动单位被先前的刺激激发时,强度增强,而当没有被激发时,强度减弱。神经中Ia纤维的阈值强度用刺激后时间直方图(PSTH)方法确定,并以50%的概率从强度中减去。这种强度被称为临界刺激(CFS),它反映了相应运动神经元的兴奋性。(4)在条件刺激前,通过对单个运动神经元施加条件刺激时CFS的变化来评估外周输入对单个运动神经元的影响。 ...更多信息 r的测试刺激。(5)将运动单位的阈值确定为临界放电水平(CFL),即运动单位放电概率为50%时复合H反射的大小.并将CFS法与传统H反射法进行了比较。(1)检查的途径是相互Ia抑制和异源Ia促进。(2)两种方法所得数据高度相关。(3)两种方法的灵敏度基本相同。(4)反射活动的存在和程度取决于运动单位.在所检查的运动单位中,有51.3%观察到从四头肌到比目鱼肌的异源性Ia易化,其频率略低于猫和猴。在紧张性胫前收缩过程中,从腓总神经到比目鱼肌的相互Ia抑制的变化一直存在争议,因为难以区分对单个运动神经元的影响和对运动神经元池的影响。CFS方法显示了对单个运动神经元的特异性影响,表明抑制作用增强。CFS法能更准确地评价单个运动神经元的反射活动,优于PSTH法的上级之处在于,CFS法不仅能在被检肌肉的随意收缩时进行检查,而且能在静息状态甚至拮抗收缩时进行检查。少
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yanagawa S et al: "Change in reciprocal Ia inhibition during tonic voluntary contraction of the antagonists.(in Japanese)" RINSHO-NOHA. 33. 389-391 (1991)
Yanakawa S 等人:“拮抗剂强直自主收缩期间 Ia 相互抑制的变化。(日语)”RINSHO-NOHA。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
進藤政臣: "Annual Revieus 神経1992" 中外医学社, 9 (1992)
Masaomi Shindo:“神经病学年鉴 1992”中外医学社,9 (1992)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
柳川宗平: "拮抗筋の持続的随意収縮による相反性Ia抑制の変化" 臨床脳波. 33. 389-391 (1991)
Sohei Yanakawa:“拮抗肌持续自主收缩导致 Ia 相互抑制的变化”临床脑电图 33. 389-391 (1991)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
進藤政臣: "運動単位発射" 脳と神経. 43. 1009-1016 (1991)
Masaomi Shindo:“运动单元发射”大脑和神经。43。1009-1016(1991)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
進藤政臣: "運動単位反射" 脳と神経. 43. 1009-1016 (1991)
Masaomi Shindo:“运动单位反射”大脑和神经。43。1009-1016(1991)
- DOI:
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- 影响因子:0
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