1,2-Diacylglycerol during the development of cardiac hypertrophy

心脏肥大发展过程中的 1,2-二酰基甘油

• 批准号: 03670447
• 负责人: ITO Takayuki
• 金额: $ 1.22万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670447/
• 关键词: 1,2-diacylglycerol; cardiac hypertrophy; SHR; monocrotaline; Thyroid hormone; cardiomyopathic hamster; 1,2-Diacylglycerol; Hypertrophy; Thyroid Hormone; RNA; Fatty Acid Composition; 1,2-diacylglycerol; hypertrophy; myopathic hamster; heart f

We studied myocardial 1,2-diacylglycerol(DG) content during the development of cardiac hypertrophy since 1,2-DG is thought to play an important role in cells by activating protein kinase C.In spontaneously hypertensive rats, 1,2-DG was elevated by 31%, but the 1,2-DG content became lower to a control level with aging. Enalapril, an angiotenin converting enzyme inhibitor, prevented the elevation of 1,2-DG.Likewise, in cardiomyopathic hamsters and rats with monocrotaline-induced right ventricular hypertrophy, elevated 1,2-DG contents were also observed in the stage of hypertrophy, Whereas this lipid was lowered at the stage of heart failure. On the other hahd, 1,2-DG was decreased in the thyroid-stimulated hypertrophy in rats because thyroid hormones directly promote protein synthesis via nuclear receptors. Pretreatment with a protein synthesis inhibitor decreased 1,2-DG more than thyroid treatment only, implying that elevated RNA inhibited the production of 1,2-DG followed by inactivating protein kinase C.Our results suggest that myocardial 1,2-DG content is associated with hypertrophy.

我们研究了心脏肥大的发育过程中心肌1,2-二酰基甘油（DG）含量，因为认为1,2-DG通过激活蛋白激酶C.in自发性高血压大鼠在细胞中起重要作用，自发性高度高度的大鼠，1,2-DG升高了31％，但1,2-DG含量较低至对照级别的粘液级别。依那普利是一种转化酶抑制剂的血管烯蛋白，在心肌病的仓鼠和具有单核苷诱导的右心室肥大的心肌病仓鼠和大鼠中，可以阻止1,2-DG。等高地升高，在超级triphereas的阶段也降低了lipid降低的心脏失败。在另一个HAHD上，大鼠甲状腺刺激的肥大中减少了1,2-DG，因为甲状腺激素直接通过核受体促进蛋白质合成。蛋白质合成抑制剂的预处理仅比甲状腺治疗降低了1,2-DG，这意味着升高的RNA抑制了1,2-DG的产生，然后抑制了蛋白激酶。您的结果表明心肌1,2-DG含量与肥大有关。

项目成果

Kenji Okumura: "Changes in ventricular 1,2-diacylglycerol content in rats following monocrotaline treatment" Cardiovascular Research. 26. 626-630 (1992)

Kenji Okumura：“野百合碱治疗后大鼠心室 1,2-二酰基甘油含量的变化”心血管研究。

Kenji Okumura,Takayuki Ito,et al: "Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension" Molecular Cellular Biochemistry. 112. 15-21 (1992)

Kenji Okumura、Takayuki Ito 等人：“依那普利在高血压形成之前可降低自发性高血压大鼠心脏中增强的 1,2-二酰甘油含量和 RNA 合成”《分子细胞生物化学》。

Takayuki Ito,et al.: "Prostaglandin H_2 as an endotheliumーderived contracting factor and its interaction with endotheliumーderived nitric oxide" Journal of Hypertension. 9. 729-736 (1991)

Takayuki Ito 等人：“前列腺素 H_2 作为内皮源性收缩因子及其与内皮源性一氧化氮的相互作用”《高血压杂志》9. 729-736 (1991)。

Kenji Okumura: "Decreased 1,2-diacylglycerol levels in myopathic hamster hearts during the development of heart failure" Journal of Molecular and Cellular Cardiology. 23. 409-416 (1991)

Kenji Okumura：“心力衰竭发展过程中肌病仓鼠心脏中 1,2-二酰甘油水平降低”《分子与细胞心脏病学杂志》。

Kenji Okumura,Takayuki Ito,et al.: "Enalapril reduces the enhanced 1,2ーdiacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension" Molecular Cellular Biochemistry.

Kenji Okumura、Takayuki Ito 等人：“在高血压形成之前，依那普利可降低自发性高血压大鼠心脏中增强的 1,2-二酰甘油含量和 RNA 合成”《分子细胞生物化学》。