1,2-Diacylglycerol during the development of cardiac hypertrophy

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We studied myocardial 1,2-diacylglycerol(DG) content during the development of cardiac hypertrophy since 1,2-DG is thought to play an important role in cells by activating protein kinase C.In spontaneously hypertensive rats, 1,2-DG was elevated by 31%, but the 1,2-DG content became lower to a control level with aging. Enalapril, an angiotenin converting enzyme inhibitor, prevented the elevation of 1,2-DG.Likewise, in cardiomyopathic hamsters and rats with monocrotaline-induced right ventricular hypertrophy, elevated 1,2-DG contents were also observed in the stage of hypertrophy, Whereas this lipid was lowered at the stage of heart failure. On the other hahd, 1,2-DG was decreased in the thyroid-stimulated hypertrophy in rats because thyroid hormones directly promote protein synthesis via nuclear receptors. Pretreatment with a protein synthesis inhibitor decreased 1,2-DG more than thyroid treatment only, implying that elevated RNA inhibited the production of 1,2-DG followed by inactivating protein kinase C.Our results suggest that myocardial 1,2-DG content is associated with hypertrophy.