Research on Pathomechanisms of Itching in Pruritic Skin Diseases

1.血液透析患者的致痒因子从大鼠腹腔分离纯化肥大细胞，与血液透析患者血清共同孵育，发现有瘙痒的血液透析患者肥大细胞组胺释放量显著高于无瘙痒的血液透析患者和正常人。虽然HD患者中组胺释放因子的性质尚不清楚，但HD患者的瘙痒可能部分由该因子引起。2.皮肤神经纤维的组织化学发现在正常皮肤中，通过针对神经纤维蛋白的新型抗体的组织化学检测，神经纤维分布在表皮和真皮中。改变了神经支配模式。3.紫外线辐射疗法的治疗机制紫外线辐射（UVR）在过敏性疾病如过敏性皮炎，特应性皮炎，和慢性肾衰竭/血液透析。它对这些疾病的有效性来自局部和全身机制。局部机制包括UVR-诱导抑制肥大细胞脱颗粒和UVR诱导的神经纤维改变，而全身机制包括UVR灭活血清中的组胺释放因子。

1.Itch-inducing factor in hemodialysis patients Mast cells were purified from rat peritoneal cavity and incubated with sera of patients undergoing hemodialysis(HD).Histamine release from mast cells was significantly higher in HD patients with itching than that in HD patients without itching or in normal subjects. Although the nature of the histamine-releasing factor in HD patients is not clear,itching in HD patients may partially be caused by this factor.2.Histochemical findings of cutaneous nerve fibers In normal skin,nerve fibers detected histochemically by novel antibodies against nerve fiber proteins were distributed in both epidermis and dermis.In pruritic skin diseases such as prurigo and psoriasis,there were altered innervation patterns.3.Therapeutic mechanisms of ultraviolet radiation therapy Ultraviolet radiation(UVR)is effective in pruritic conditions such as prurigo,atopic dermatitis,and chronic renal failure/hemodialysis.Its effectiveness in these diseases results from both local and systemic mechanisms.Local mechanisms include UVR-induced suppression of mast cell degranulation and UVR-induced nerve fiber alterations,while systemic mechanisms include inactivation by UVR of the histamine-releasing factor in sera.