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Possible involvement of the parasympathetic cerebrovascular innervation in regulation of cerebral blood flow

副交感脑血管神经支配可能参与脑血流的调节

基本信息

批准号：
03670680
负责人：
HARA Hideaki
金额：
$ 1.54万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

1. Effect of acute cerebral arterial occlusion on the distribution of cerebral perivascular innervation.The results of the study indicate that the different modes of cerebral arterial occlusion have variable effects on the perivascular innervation. Arterial occlusion induced either by the intraluminal maneuvers of the cerebral artery or the transient extracranial procedures does not impare cerebral perivascular innervation at least up to 3 days. To the contrary, cerebral arterial occlusion with extraluminal electrocoagulation diminishes perivascular nerves around the occluded cerebral artery.2. Effect of subarachnoid hemorrhade on the distribution of the supraependymal serotonergic nerve.A marked reduction in supraependymal serotonin immunostaining was observed in rats sacrificed as early as 6 h post subarachnoid hemorrhage and this change continued until 14 days and recovered by 28 days following subarachnoid hemorrhage.3. Glycerol injection to the rat trigeminal ganglion.The effect of topical glycerol injection to the rat trigeminal nerves was investigated histologically and immunohistochemically. The study suggested that topical glycerol injection into the trigeminal nerve induced degeneration of the nerve immunoreactive to CGRP and SP.4. Anterograde tracing of the parasympathetic nerve from the sphenopalatine ganglion.The observations with the anterograde tracing technique with WGA-HRP revealed that the parasympathetic innervation of the major cerebral arteries was derived from the sphenopalatine ganglion via the ethmoidal arteries which connect in a collateral anastomotic fashin with the intracranial arteries.

1.急性脑动脉闭塞对脑血管周围神经分布的影响本研究结果表明，不同的脑动脉闭塞方式对脑血管周围神经分布的影响是不同的。由脑动脉腔内操作或短暂颅外操作引起的动脉闭塞至少在3天内不会影响脑血管周围神经支配。相反，脑动脉闭塞与腔外电凝减少闭塞脑动脉周围的血管周围神经。蛛网膜下腔出血对大鼠室管膜上5-羟色胺能神经分布的影响蛛网膜下腔出血后6 h处死的大鼠室管膜上5-羟色胺免疫染色明显减少，这种变化持续到14 d，并在蛛网膜下腔出血后28 d恢复.三叉神经节局部注射甘油，观察甘油对三叉神经的影响。本研究表明，局部甘油注射到三叉神经诱导神经变性的CGRP和SP的免疫反应。蝶腭神经节的副交感神经顺行追踪应用WGA-HRP顺行追踪技术观察，发现大脑主要动脉的副交感神经支配来自蝶腭神经节，经筛动脉与颅内动脉侧支吻合。