骨髄移植における移植片対宿主反応へのヒト組織適合性抗原の関与についての研究

人组织相容性抗原参与骨髓移植移植物抗宿主反应的研究

• 批准号: 03671183
• 负责人: 森島 泰雄
• 金额: $ 0.9万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03671183/
• 关键词: 骨髄移植; HLA

他人からの同種骨髄移植にとり、ドナ-と患者との組織適合性抗原の一致が重要であり、特に移植後生じる急性GVHD発症に関し問題になってくる。本研究では、HLAの適合した血縁者および非血縁者よりの白血病同種骨髄移植症例について、上記の点につき解析し、次のような知見を得た。1。HLAーA、B、DR適合、MLC陰性兄弟をドナ-とする同種骨髄移植における急性GVHDの頻度はGVHD予防としてメトトレキセ-トとシクロスポリン併用療法を実施した場合に、中等症以上の急性GVHDは5%の症例に生じた。この頻度は欧米での白人間の同種骨髄移植の頻度約30%に比べ低頻度であった。このことから、HLA遺伝子型適合骨髄移植における急性GVHD発症にはHLA以外の未知なる組織適合性が関与している事が推論された。2。HLAーA,B,DRが適合し、リンパ球混合培養試験(MLC)が陰性(Relative Response Index 20以下)の非血縁者をドナ-とした非血縁者間移植を4症例に実施した成績では、急性GVHDは軽症(1度)が2症例に生じただけで、他の2症例では急性GVHDは生じなかった。1症例ではHLAーDP型に違いがあるにもかかわらず、MLC陰性で急性GVHDも(-)であった。。この頻度は欧米の白人間の同様な骨髄移植の報告に比べ低率であり、日本人間で組織適合性抗原(HLA抗原とnonーHLA抗原)の多様性が少ない事を意味している。現在これら症例につきHLAーDR,DQのDNAタイピングを実施中である。

The patients who received the same bone transplantation, the patients who received the same bone transplantation, the patients who had the same sex antigen, and the patients who had received the same bone transplant, and the patients who had received the same kind of bone transplant, and the patients who had received the same kind of bone transplantation, and the patients who had received the same kind of bone transplantation, and the patients who had received the same bone transplant, and the patients who had received the same bone transplantation had the same sex antigens in their tissues. In this study, the cases of bone transplantation in non-blood patients with leukemia in this study were compared, the results were analyzed at the last memory point, and the results were obtained in the second half of the study. one. HLA A, B, DR combination, MLC Sex Brothers, Thoracic Bone Transplantation, Acute GVHD Transplantation, GVHD to prevent the occurrence of acute GVHD, the use of antiretroviral therapy, the use of drug therapy, moderate and above acute GVHD 5% of the disease. The degree of transplantation of the same bone between whites was about 30% higher than that of low-grade bone grafts. The combination of bone graft and HLA subtype bone graft was not known in patients with acute GVHD syndrome, but in addition to HLA. two. There were 4 cases of acute GVHD syndrome, 2 cases of acute GVHD syndrome (1 degree), 2 cases of acute GVHD syndrome, and 2 cases of acute GVHD syndrome. One case was diagnosed as having acute GVHD (-) and MLC (-) in the first case. The low rate of bone transplant was reported in Olympian white donors, and the multiplicity of HLA antigens (HLA antigens, nonspecific HLA antigens) in Japanese tissues meant that there was no bone graft in Japanese. At present, there are many cases of illness, such as HLA, DR,DQ, DNA, and the implementation of the disease is in progress.