权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of the Resins having Antibacterial Activity

具有抗菌活性的树脂的研制

基本信息

批准号：
03555196
负责人：
NONAKA Takamasa
金额：
$ 5.38万
依托单位：
Kumamoto university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

Copolymer beads having chlorohysroxyl group (RCG) were prepared by treating macroreticular glycidyl methacrylate-divinylbenzene copolymer beads with hydrogen chloride. Copolymer beads bearing quaternary ammonium groups or phosphonium groups were prepared by treating RCG or stirene tetraethyleneglycol dimethacrylate(RCS4G) with amines or phosphines. Triethyl amine, N, N-dimethyl-n octhylamine N, N-dimethyl-n-dodecylamine(DMDA), N, N-dimethy-n-hexadecylamine were used as amine. Triethyl phosphine (TEP), Tributyl phosphine (TBP), and Trioctyl phosphine (TOP), and so on were used as phosphine. The adsorption of sodium benzenesulfonate(SBS), sodium n-dodecylbenzenesulfonate (SDBS), and bacteria with the resins containing quaternary ammonium groups(RCG-Q or RCS4G-Q) was investigated under various conditions. And their antibacterial activity was examined against Escherichia col (E.coli) and Staphylococcus aureus (S.aureus).RCG-Q and RCS4G-Q had antibacterial activity against E.coli and S.aureus.SBS and SDBS could be adsorbed with RCG-Q from the solution over wide pH(4.5-8.5) range and with ionic strength (0-0.3). RCG-TOP(OH type) exhibited antibacterial activity against E.coli in water, but RCG-TEP and RCG-TBP had no activity. Scanning electron micrograph showed that bacteria were adsorbed on those resins. Both antibacterial activity and adsorption ability of the resins were not only affected by the structures of quaternary ammonium groups or phosphonium groups but also the kinds of matrix of copolymer bead into which those functional groups introduced.

通过用氯化氢处理大网状甲基丙烯酸缩水甘油酯-二乙烯基苯共聚物珠粒来制备具有氯代环氧丙基基团（RCG）的共聚物珠粒。通过用胺或膦处理RCG或苯乙烯四甘醇二甲基丙烯酸酯（RCS 4G）来制备带有季铵基团或鏻基团的共聚物珠粒。三乙胺、N，N-二甲基-正辛胺、N，N-二甲基-正十二胺（DMDA）、N，N-二甲基-正十六胺用作胺。三乙基膦（TEP）、三丁基膦（TBP）和三辛基膦（TOP）等用作膦。研究了不同条件下含季铵基树脂（RCG-Q和RCS 4G-Q）对苯磺酸钠（SBS）、十二烷基苯磺酸钠（SDBS）和细菌的吸附性能。结果表明，RCG-Q和RCS 4G-Q对大肠杆菌和金黄色葡萄球菌具有较好的抗菌活性，在较宽的pH范围（4.5-8.5）和离子强度范围（0 ~ 0.3）内，RCG-Q对SBS和SDBS均有较好的吸附作用。RCG-TOP（OH型）对水中大肠杆菌具有抗菌活性，而RCG-TEP和RCG-TBP对水中大肠杆菌无抗菌活性。扫描电子显微镜显示细菌被吸附在树脂上。树脂的抗菌活性和吸附能力不仅与季铵基或季鏻基的结构有关，还与引入季铵基或季鏻基的共聚物微球基体的种类有关。