レーザードプラー皮膚組織血流量計による麻酔深度・ストレス反応モニタの開発

激光多普勒皮肤组织血流量计麻醉深度和应激反应监测仪的研制

• 批准号: 03557065
• 负责人: 吉矢 生人
• 金额: $ 5.31万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03557065/
• 关键词: レーザードプラー血流量計; 皮膚組織血流; ストレス反応; 交感神経反射; 揮発性麻酔薬; MAC BAR; レ-ザ-ドプラ-血流量計; 麻酔深度

平成4年度の研究では、作成したストレス反応モニタシステムを用いて麻酔中の皮膚切開に伴う皮膚組織血流量の一過性低下反応出現の有無を調べ、各麻酔薬のMAC BAR(MAC that blocked the adrenergicresponse)を求めた。同時に血行動態と血中ノルエピネフリン濃度を経時的に測定し、皮膚組織血流の一過性低下反応が侵害刺激に対する交感神経反応を反映するかどうかを検索した。対象は65名のASA分類I-II度の予定手術患者で、無作為にハロセン(H群N=17)、エンフルレン(E群N=14)、イソフルレン(I群N=16)およびセボフルレン(S群N=18)単独麻酔の4群に分けて調べた。皮膚切開に伴う一過性低下反応出現の有無によって、Dixonのup-and-down法にしたがってMAC BARを求めた。得られたMAC BAR値は、ハロセン1.35%(1.75MAC)、エンフルレン2.25%(1.34MAC)、イソフルレン2.01%(1.75MAC)、セボフルレン2.77%(1.62MAC)であった。ハロセン、イソフルレンおよびセボフルレンでは近似したMAC値であったが、エンフルレンでは他の麻酔薬に比べてかなり小さな値となった。一方、皮膚切開前後のRPP(rate pressure product)の増加は4群共に一過性低下反応が出現した症例群で出現しなかった症例群に比べて大きいかまたは大きい傾向がみられた。また、4群共に、皮膚切開前後の血漿ノルエピネフリン濃度の増加の程度も、一過性低下反応が出現した症例群で出現しない症例群よりも大きいかまたはその傾向がみられた。以上の結果から、皮膚組織血流の一過性低下反応は侵害刺激に対する交感神経反応を反映していると結論した。本研究において作成したレーザー・ドプラー組織血流量計を用いたストレス反応モニタシステムは麻酔中のストレスに対する交感神経反応モニタとして臨床的に有用であると考えられる。

In Pingcheng 4, the tissue blood flow of the skin was cut open and the tissue blood flow of the skin was cut open and the tissue blood flow of the tissue was found that there were no symptoms in the study in Pingcheng in the fourth year of the study, and the results showed that the tissue blood flow of the tissue with the skin was cut open and the tissue blood flow of the tissue was reduced. The results showed that there were no blood flow in the tissue, and the results showed that there were no blood flow in the tissue, and the results showed that the tissue blood flow of the tissue was low. At the same time, the determination of the blood flow in the blood and the blood flow of the skin tissue were measured during the period of blood dynamics, and the blood flow of the skin tissue was affected by low sex, anti-invasion stimulation, sympathetic response, sympathetic response, response and response. For example, 65 ASA classified I-II patients were classified as surgical patients, none of them were classified as surgical patients (group H, group 17), group E (group 14), group I (group I, 16) and group 18 (group 18). As soon as the skin was cut open and accompanied by low sex, it was found that there were abnormal symptoms, Dixonucleus up-and-down method to detect MAC BAR symptoms. The score is 1.35% (1.75MAC), 2.25% (1.34MAC), 2.01% (1.75MAC), 2.77% (1.62MAC), respectively. I don't know. I don't know. One side, the skin cut before and after the treatment of RPP (rate pressure product) plus a total of 4 groups, a total of cases of hypotrophies were found in the group of cases of dyspnea, and the number of cases of cases of dysentery was higher than that of the patients. The patients were divided into four groups, and the blood samples were cut before and after the skin incision, and there was an increase in the severity of the disease before and after the incision of the dermectomy. as soon as there were cases of sexual hypotension, there was a group of symptoms. As a result of the above results, the blood flow of the skin tissue is affected by sexual hypotrophies, responses, stimuli, sympathetic responses, sympathetic responses, and responses. The purpose of this study is to measure the tissue blood flow in order to measure the blood flow of the tissue.

项目成果

真下 節,瀬戸 倫義,吉矢 生人: "全身麻酔下のストレス反応モニタとしてのレ-ザ-ドプラ-組織血流量計"

Setsu Mashita、Michiyoshi Seto、Ikuto Yoshiya：“激光多普勒组织血流计作为全身麻醉下的应激反应监测仪”