Development of a reduced energy type implantable defibrillator.

开发低能量型植入式除颤器。

• 批准号: 03650320
• 负责人: MAKINO Hideo
• 金额: $ 1.22万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03650320/
• 关键词: Implantable defibrillator; Cardiomyoplasty; Arrhythmia detection; Interval histogram; 不整脈検出; 除細動エネルギ-

In 1992, the research was focused on the basic animal experiments. In particular, the stability of the pacing function was confirmed in chronic experiments.1) Confirmation of arrhythmia detection methodTo develop a new arrhythmia detection method, we used the interval histogram method for ECG, and we made an on-line real time detection program to analyze the frequency variation of the ECG. After that, we installed the program into a battery-type arrhythmia detection circuit, and confirmed its function during in-vivo test.2) Development of an implantable stimulation unit and experimental resultsThe arrhythmia detection circuit and the output circuit were developed. The detection circuit was used to execute the interval histogram method and muscle stress sensing. The output circuit has the capability of cardiac pacing and muscle stimulation for cardiomyoplasty. Both pacing and muscle stimulation function were confirmed in acute animal experiments using mongrel dogs. Moreover, the implantable units were stable more than 4 weeks in chronic experiments.In the future, for arrhythmia sensing, we will combine a database which contains various ECG data with the detection program to develop a personal oriented detection system. Moreover, we will also make effort to assemble the new implantable system with defibrillation, cardiac pacing and cardiomyoplasty functions for use in chronic animal experiments.

1992年，研究重点放在基础动物实验上。1）心律失常检测方法的确定为了开发一种新的心律失常检测方法，我们采用了心电图的间期直方图法，并编制了一个在线的真实的时间检测程序，分析了心电图的频率变化。然后将程序安装到电池型心律失常检测电路中，并在体内试验中验证了其功能。2）植入式刺激单元的研制及实验结果研制了心律失常检测电路和输出电路。检测电路用于执行间隔直方图法和肌肉应力传感。输出电路具有心脏起搏和肌肉刺激的能力，用于心肌成形术。起搏和肌肉刺激功能在急性动物实验中使用杂种狗证实。在未来的心律失常侦测方面，我们将以联合收割机结合各种心电资料的资料库与侦测程式，发展出个人化的侦测系统。此外，我们还将努力组装具有除颤、心脏起搏和心肌成形术功能的新型植入式系统，用于慢性动物实验。

项目成果

Hideo Makino: "Onーline fibrillation sensing circuit for implantable defibrillator using ECG interval histogram method" Proc.13th annual international meetings of IEEE EMBS. 13. 743-744 (1991)

Hideo Makino：“使用 ECG 间隔直方图方法的植入式除颤器的在线颤动传感电路”Proc.13th IEEE EMBS 国际年会 13. 743-744 (1991)。

佐藤 栄一: "Cardiomyoplastyにおける加速度センサによる刺激制御" 電子情報通信学会技術研究報告.

Eiichi Sato：“在心肌成形术中使用加速度传感器进行刺激控制”IEICE 技术研究报告。

佐藤 栄一: "植込み型骨格筋刺激装置の開発" 平成4年度電子情報通信学会信越支部大会予行集. 335-336 (1992)

Eiichi Sato：“植入式骨骼肌刺激器的开发”1992 年电子、信息和通信工程师学会信越分会会议记录 335-336 (1992)。

Makio Hideo: "An Implantable Skeletal Muscle Stimulator with a Vibration Sensor." 5th AsianーPacific Symposium on Cardiac Pacing and Electrophysiology.

Makio Hideo：“带有振动传感器的植入式骨骼肌刺激器。”第五届亚太心脏起搏和电生理学研讨会。

Hideo Makino: "A sequencial implantable defibrillator using interval histogram sensing method" IEEE Transaction on Biomedical Engineering. (1992)

Hideo Makino：“使用间隔直方图传感方法的顺序植入式除颤器”IEEE 生物医学工程汇刊。