Blood Flows in Stenotic/Collapsible Vessels

狭窄/塌陷血管中的血流

• 批准号: 04305008
• 负责人: MATSUZAKI Yuji
• 金额: $ 3.84万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04305008/
• 关键词: self-excited oscillation; two-dimensional flow channel model; Aorta; coronary artery; collapsible tube; slosh phenomena; three-dimensional numerical analysis; 1次元剥離流れ理論; つぶれ易い管

The present group research was focussed on blood flow-vessels interaction problems, covering blood flows in coronary arteries with stenosis, a brachial one under a pnuematic cuff, and bifurcating or bent ones as well as collspaible venous vessels. The study was carried out with close collaboration of biomechanical engineers and scientists and is divided into two areas, i. e., arterial and venous vessels systems.As for the former, 1) F.Kajiya measured septal artery blood velocities under several control conditions on the stenosis, and examined the effect of coronary stenosis on phasic pattern of septal artery, 2) R.Yamaguchi measured variation of wall shear stress around axisymmetric stenosis in steady and pulsatile flows using an electrochemical method, 3) K.Tanishita studied the pulsatile flow in bend tube also examined the oxygen transport in cultured endothelial cells, 4) T.Yamaguchi carried out a three-dimensional numerical analysis of unsteady flow and wall shear stress in the models of arterial blood vessels and left ventricel, and 5) M.Shimuzu studied experimentally and theoretically the characteristics of blood flow in a brachial artery compressed by a pneumatic cuff to clarify the basic principle of the auscultatory technique.As for the venous flow, 1) K.Ohba performed a systematic experiment on the effect of longitudinal tension on the behavior of the flow through collapsible tubes, 2) T.Yamane also experimentally examined the effect of hysteresis due to the tube and the fluid property on the static and dynamic behavior of the tube conveying the flow, 3) S.Hayashi measured the static and dynamic characteristics of the collapsed tubes to compare to his numerical analyzes, and 4) Y.Matuzaki performed a numerical analysis of self-excited oscillation of the flow-tube by taking into account the effect of flow separation.

目前的小组研究集中在血流-血管相互作用问题，包括狭窄的冠状动脉，在一个pnuematic袖带下的肱动脉，分叉或弯曲的以及collspaible静脉血管的血流。这项研究是在生物力学工程师和科学家的密切合作下进行的，分为两个领域，即，对于前者，1）F.Kajiya在狭窄的几种控制条件下测量了间隔动脉血流速度，并检查了冠状动脉狭窄对间隔动脉相位模式的影响，2）R.Yamaguchi用电化学方法测量了稳态和脉动流中轴对称狭窄周围的壁切应力变化，3）K.Tanishita研究了弯曲管中的脉动流，也研究了培养的内皮细胞中的氧输送。4）T.Yamaguchi在动脉血管和左心室模型中进行了非定常流和壁面切应力的三维数值分析，5）Shimuzu先生从实验和理论上研究了被充气袖带压缩的肱动脉中的血流特性，以阐明听诊技术的基本原理。至于静脉流，1）K.Ohba对纵向张力对通过可折叠管的流动行为的影响进行了系统的实验，2）T.Yamane还通过实验研究了由于管和流体性质引起的滞后对输送流体的管的静态和动态行为的影响，3）S.Hayashi测量了塌陷管的静态和动态特性以与他的数值分析进行比较，4）Y.Matuzaki在考虑流动分离效应的情况下，对流管的自激振荡进行了数值分析。

项目成果

西田正浩: "対称分岐管内振動流における軸方向の評価" 日本機械学会論文集. 417-424 (1994)

Masahiro Nishida：“对称支管中振荡流的轴向方向的评估”日本机械工程师学会会刊 417-424 (1994)。

池田忠繁: "振動する狭窄を持つ二次元流路内の剥離流れ:数値解析と実験" 日本機械学会論文集. 60-571B. (1994)

Tadashige Ikeda：“具有振动收缩的二维流道中的分离流：数值分析和实验”日本机械工程师学会汇刊 60-571B (1994)。

T.Yamaguchi: "A Parametrically Defined Computational Fluid Mechanical Model for the Study of the Flow in Arterial Bifurcations" Journal of Biomechanical Engineering. (submitted). (1993)

T.Yamaguchi：“用于研究动脉分叉流动的参数化定义的计算流体力学模型”生物力学工程学杂志。

谷下一夫、松崎雄嗣 ほか: "バイオメカニクス概説" オーム社, 209 (1993)

Kazuo Tanishita、Yuji Matsuzaki 等：“生物力学概述”Ohmsha，209 (1993)

T.Yamaguchi: "Do Vascular Endothelial Cells Sense a Uniform Shear Stress ? - A Computational Fluid Mechanical Study Using Models of Cultured Endothelial Cells" Microcirculation Annual. Vol.9. 166- (1993)

T.Yamaguchi：“血管内皮细胞感知均匀的剪切应力吗？ - 使用培养内皮细胞模型的计算流体力学研究”微循环年鉴。