A basic study for the clinical application of a totally implantable artificial heart system including the drive system

含驱动系统的全植入式人工心脏系统临床应用的基础研究

• 批准号: 04557058
• 负责人: NITTA Shinichi
• 金额: $ 11.14万
• 依托单位: Institute of Development, Aging & Cancer, Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557058/
• 关键词: Total artificial heart; Totally implantable system; percutaneous energy transmission; amorphous fiber; vibrating flow pump; high frequency pump generation; control of blood distribution; vascular impedance; Totally implantable; Total artificial h

Tohoku University artificial heart group proposed a new drive mechanism for a total artificial heart (TAH) which produces the vibrating flow in the high frequency area between 3 to 50 Hz. This vibrating flow pump (VFP) has been developing as a totally implantable TAH system because of following advantageous characteristics.a.simple in drive mechanism and pump structureb.high frequency generation (miniaturized TAH,possibility to have control method of blood distribution by changing the drive frequencies.c.a single valved.one way flow streamhigh efficient transcutaneous electric power transmission systemHemolysis studyThe values of plasma Hb after pumping of the VFP showed the almost same value as a commercially available centrifugal and roller pumps which was thought to be an acceptable value as clinical use in the ex vivo hemolysis tests.Pump description and design improvementThe VFP consists of mainly an inlet and outlet cannulae, a vibrational tube with surrounded electric coils and an outflow valve. The improvement of the pump design was achieved from the information by the use of the flow visualization and hemolysis study.Transcutaneous energy transmission system (TETS)TETS is developed by the use of a primary and a secondary amorphous coils across the skin in the distance between 2,4 and 6mm showing 16,15, and 13% as the values of the total efficiencies of the drive system, respectively.Animal experimentsAdult goats were used for pump fitting studies, acute hemodynamic, hemolysis evaluations and subchronic studies using VFPs as totally implantable TAH.In the details, see following papers.

东北大学人工心脏研究小组提出了一种新的全人工心脏（TAH）驱动机制，该机制可在3至50 Hz的高频区域产生振动流。这种振动流泵（VFP）由于具有以下优点而被开发为完全可植入的TAH系统：a.驱动机构和泵结构简单b.高频发生（小型化TAH，通过改变驱动频率来控制血液分布的可能性c.valved.one路流动流高效经皮电力传输系统溶血研究VFP表现出几乎相同的值作为一个商业可用的离心泵和滚子pumps这被认为是一个可接受的值作为临床使用在ex-vivo hemolysis tests.Pump描述和设计改进VFP主要由一个入口和出口插管，一个振动管与周围的电线圈和流出阀。经皮能量传输系统（TETS）TETS是通过使用初级和次级非晶线圈穿过皮肤在2，4和6 mm之间的距离显示16，15和13%作为驱动系统的总效率的值而开发的。动物实验用成年山羊进行了VFP作为完全植入式TAH的泵装配研究、急性血流动力学、溶血评价和亚慢性研究，详见下文。

项目成果

Tomoyuki Yambe: "New Artificial Heart Control Method from the Neurophysiological Point of View" Artificial Heart 4. 353-356 (1993)

Tomoyuki Yambe：“从神经生理学角度看新的人工心脏控制方法”Artificial Heart 4. 353-356 (1993)

S.Nitta,et al.: "Carotid Arterial Impedance During Oscillated Blood Flow" Artificial Organs. 18(9). 627-632 (1994)

S.Nitta 等人：“振荡血流期间的颈动脉阻抗”人造器官。

永沼 滋,仁田 新一,他: "ガス交換能から検討した電磁駆動式ポンプの膜型人工心肺への応用" 人工臓器. 21. 682-687 (1992)

Shigeru Naganuma、Shinichi Nita 等人：“基于气体交换能力的电磁驱动泵在膜心肺机中的应用”《人工器官》21. 682-687 (1992)。

S.Nitta, et al.: "Effect of Artificial Hight-Frequency Generation on Hemodynamic Properties" Progress in Microcirculation Research. 459-462 (1994)

S.Nitta 等人：“人工高频产生对血流动力学特性的影响”微循环研究进展。

仁田新一: "完全体内埋め込み型補助人工心臓システムの開発" 人工臓器. (印刷中).

Shinichi Nita：“开发完全植入式辅助人工心脏系统”人工器官（正在出版）。