Development of an intra aortic respiratory and circulatory assist system.

心力衰竭和呼吸衰竭是影响心内直视手术效果的主要因素，如果能提供一个非常简单、容易建立的呼吸和心脏辅助系统，就可以挽救更多的心脏手术后患者的生命。为了开发这样的打捞系统，我们瞄准了中空纤维的特性，它允许在抽油周期中具有足够的体积位移。该系统将直径1.0 cm的硅橡胶或弹性中空纤维球囊插入降主动脉，作为膜式柔性氧合器和脉动驱动系统，采用氧气驱动的IABP系统，可同时获得呼吸和心脏辅助。弹性气球是由丙纶制成的，其膜厚0.05 mm，有一定的体积位移。在模拟循环中对这两种材料进行了评价。充当…成员的中空纤维气球br更多的ANE发起者表现出弹性不足，不能有30ml的容量移位。另一方面，硅橡胶膜具有足够的输氧率和弹性，但在耐久性试验中缺乏耐久性。这些结果表明，要想获得理想的体积置换氧合器，必须改变后续纤维和硅橡胶膜的设计。当时我们得出的结论是，必须选择更高的泵代频率来节省体积置换，这样可以将使用振动流量泵(VFP)的每一冲程体积从50-80毫升降至60 1/10-1/30。与离心泵相比，外径0.5 mm和1.0 mm的VFP在相同的心输出量下，在10-30 Hz的频率下，氧合效率是离心泵的2倍。这些结果表明，使用膜式氧合器和VFP系统建立完全可植入的心肺机系统是可能的。我们也证明了在主动脉内同时进行氧合和泵送系统的可能性，特别是对于心脏手术后的患者。较少

Not only cardiac failure but also respiratory failure mainly affects the results of the open heart surgery.If we can provide the system of very simple and easy to establish the respiratory and cardiac assist system, we can save more patient after cardiac surgery. To develop a such salvaging system we aim at the characteristics of hollow fiber which permits to have elasticity to make sufficient volume displacement during pumping cycle. With this system, we can obtain the respiratory and cardiac assist at the same time.This system is inserted into the descending aorta which mainly consists of a silastic or elastic hollow fiber balloons in a bundle 1.0 cm in diameter as a membrane flexible oxygenator and pulsatile drive system, such an IABP system using oxygen drive. The elastic balloon which shows some volume displacement is made of propiren their membrane 0.05 mm thick. These two kinds of materials were evaluated in the mock circulation. The balloon of hollow fiber which acts as a membr … More ane originator showed not sufficient elasticity to have 30 ml volume displacement. On the other hand silastic membrane showed an adequate oxygen delivery rate and elasticity, but lack of durability in the endurance tests. These results indicate that we have to change the design of follow fibers and silastic membrane for ideal volume displacement oxygenator.At that time we concluded that we have to save the volume displacement by choosing more higher frequency of pump generation which can minimize the every stroke volume from 50 - 80 ml 60 1/10 - 1/30 of it using our vibrating flow pump (VFP) .Thin hollow fiber 0.05 mm thick, 0.5 and 1.0 mm in outside diameter showed 2 times of oxygenation rate using VFP in the generation frequency of 10-30Hz in the same cardiac output compare to the centrifugal pump.These results indicate the possibility to have a totally implantable heart and lung machine system using the membrane oxygenator and VFP system.Also we proved the possibility to make a simultaneous oxygenation and pumping system in the aorta especially for patients after cardiac surgery. Less